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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
1987-12-14
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pubmed:abstractText |
A conjugate vaccine (Dpo20) was made by direct coupling of diphtheria toxoid and oligosaccharides obtained by periodate oxidation of Haemophilus influenzae type b capsular polysaccharide. This approach gave a higher multiplicity of saccharides per protein and greater immunogenicity in infancy than our previously studied conjugates. Thirty-three healthy infants received three sequential injections, and no serious side effects were observed. When Dpo20 was given with diphtheria-tetanus-pertussis vaccine at ages 2, 4, and 6 months, the geometric mean titer of anticapsular antibody rose to 5.9 micrograms/ml at age 7 months. Dpo20 given at 3, 5, and 7 months raised the mean to 3.2 micrograms/ml at 7 months (after two injections) and 15.4 micrograms/ml at 10 months. The antibodies included IgG and were bactericidal in vitro. Thus, antibody activities potentially protective against invasive H. influenzae b infections were induced in the most susceptible age range. The infants also became primed for mature-for-age responses to (unconjugated) polysaccharide vaccine given as a booster at age 12 months.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Bacterial,
http://linkedlifedata.com/resource/pubmed/chemical/Bacterial Capsules,
http://linkedlifedata.com/resource/pubmed/chemical/Bacterial Vaccines,
http://linkedlifedata.com/resource/pubmed/chemical/Diphtheria Toxoid,
http://linkedlifedata.com/resource/pubmed/chemical/Diphtheria-Tetanus-Pertussis Vaccine,
http://linkedlifedata.com/resource/pubmed/chemical/Drug Combinations,
http://linkedlifedata.com/resource/pubmed/chemical/Haemophilus Vaccines,
http://linkedlifedata.com/resource/pubmed/chemical/Haemophilus influenzae type b...,
http://linkedlifedata.com/resource/pubmed/chemical/Haemophilus influenzae type...,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulins,
http://linkedlifedata.com/resource/pubmed/chemical/Pertussis Vaccine,
http://linkedlifedata.com/resource/pubmed/chemical/Polysaccharides, Bacterial,
http://linkedlifedata.com/resource/pubmed/chemical/Tetanus Toxoid
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0022-3476
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
111
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
644-50
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:3499499-Age Factors,
pubmed-meshheading:3499499-Antibodies, Bacterial,
pubmed-meshheading:3499499-Bacterial Capsules,
pubmed-meshheading:3499499-Bacterial Vaccines,
pubmed-meshheading:3499499-Diphtheria Toxoid,
pubmed-meshheading:3499499-Diphtheria-Tetanus-Pertussis Vaccine,
pubmed-meshheading:3499499-Drug Combinations,
pubmed-meshheading:3499499-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:3499499-Haemophilus Vaccines,
pubmed-meshheading:3499499-Haemophilus influenzae,
pubmed-meshheading:3499499-Humans,
pubmed-meshheading:3499499-Immunization, Secondary,
pubmed-meshheading:3499499-Immunoglobulins,
pubmed-meshheading:3499499-Infant,
pubmed-meshheading:3499499-Pertussis Vaccine,
pubmed-meshheading:3499499-Polysaccharides, Bacterial,
pubmed-meshheading:3499499-Tetanus Toxoid
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pubmed:year |
1987
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pubmed:articleTitle |
Priming and induction of Haemophilus influenzae type b capsular antibodies in early infancy by Dpo20, an oligosaccharide-protein conjugate vaccine.
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pubmed:affiliation |
Department of Pediatrics, University of Rochester, NY.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.
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