Linked Life Data

3499420

Source:http://linkedlifedata.com/resource/pubmed/id/3499420

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1987-12-17
pubmed:abstractText
Murine respiratory mycoplasmosis (MRM), due to Mycoplasma pulmonis, is a chronic respiratory disease in laboratory rats. LEW and F344 rats differ in the severity and progression of disease. LEW rats develop more severe disease than do F344 rats. Also, F344 rats are able to resolve lung and middle ear lesions, but the severity of these lesions in LEW rats continues to increase. LEW lymphocytes produce higher responses in vitro to various mitogens, including M. pulmonis mitogen, than do F344 lymphocytes; this difference is apparently due to higher levels of T-helper cells in LEW rats. The level of infiltration or expansion of mononuclear cells in the submucosa probably depends upon the host's ability to respond to nonspecific stimuli. In contrast to nonspecific responses, F344 rats produce a much higher specific antibody and cellular response to M. pulmonis antigens after immunization, suggesting that F344 rats, in contrast to LEW rats, are able to resolve lesions because they are able to mount an effective immune response to M. pulmonis.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0021-2180
pubmed:author
pubmed:issnType
Print
pubmed:volume
23
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
485-9
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1987
pubmed:articleTitle
Specific vs. nonspecific immune responses in murine respiratory mycoplasmosis.
pubmed:affiliation
Department of Microbiology, University of Alabama at Birmingham 35294.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't