Linked Life Data

3499253

Source:http://linkedlifedata.com/resource/pubmed/id/3499253

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11
pubmed:dateCreated
1987-12-7
pubmed:abstractText
Prolonged (90 min) incubation with the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) causes no significant changes in the elemental composition of whole rabbit thymocytes (25 elements included). The only exception is the amount of magnesium, where a significant increase can be detected. However TPA preincubation elicits the redistribution of heavy metals (mainly Zn and to a much lesser extent Fe and Cu) from the nuclear and large granular (mitochondrial-lysosomal) fraction to the cytosol and microsomes. A significant translocation of calcium and phosphorus from the large granular fraction mainly to the nucleus can also be observed. The TPA-induced heavy metal depletion of the nucleus might play a role in the antiproliferative activity of TPA, the arrest of G1----S phase transition. On the other hand the increased amount of heavy metals in the cytosol might be linked to the TPA-induced block of intercellular communication and the desensitization of TPA-treated cells towards extracellular calcium which are well-known properties of neoplastic cells.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0143-3334
pubmed:author
pubmed:issnType
Print
pubmed:volume
8
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1663-6
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1987
pubmed:articleTitle
The tumor promoter tetradecanoylphorbol-13-acetate elicits the redistribution of heavy metals in subcellular fractions of rabbit thymocytes as measured by plasma emission spectroscopy.
pubmed:affiliation
Institute of Biochemistry I., Semmelweis University School of Medicine, Budapest, Hungary.
pubmed:publicationType
Journal Article