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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
1987-12-16
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pubmed:abstractText |
Highly purified and cloned preparations of interleukin-1 (IL-1) were found to antagonize the capacity of erythropoietin (Epo) to stimulate the proliferation of mouse spleen and bone marrow erythroid precursor cells (EPC) in culture. Cloned murine IL-1 and purified and cloned human IL-1 alpha and IL-1 beta were approximately equipotent in this assay. IL-1 inhibited the proliferation response of EPC even when added as long as 17 h after Epo, suggesting that IL-1 does not affect binding of Epo to receptors or biochemical events following shortly thereafter. Indomethacin did not influence the inhibitory effect of IL-1 on Epo-induced proliferation, and PGE2 had no demonstrable effect on the process. Tumor-necrosis factor-alpha and interferons beta 1, and gamma did not affect Epo-induced proliferation. It is suggested that IL-1 mediated antagonism of the effects of Epo on erythroid precursors is a factor in the pathogenesis of many types of hypoplastic anaemia, including those associated with infections, rheumatoid arthritis and systemic lupus erythematosus, giant-cell arteritis, graft-versus-host disease and disorders associated with lymphocyte-mediated suppression of erythropoiesis.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0007-1048
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
67
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
11-7
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:3499170-Anemia,
pubmed-meshheading:3499170-Anemia, Aplastic,
pubmed-meshheading:3499170-Animals,
pubmed-meshheading:3499170-Bone Marrow,
pubmed-meshheading:3499170-Cell Division,
pubmed-meshheading:3499170-Cells, Cultured,
pubmed-meshheading:3499170-Erythroblasts,
pubmed-meshheading:3499170-Erythropoietin,
pubmed-meshheading:3499170-Female,
pubmed-meshheading:3499170-Growth Inhibitors,
pubmed-meshheading:3499170-Hematopoietic Stem Cells,
pubmed-meshheading:3499170-Interleukin-1,
pubmed-meshheading:3499170-Mice,
pubmed-meshheading:3499170-Spleen,
pubmed-meshheading:3499170-Tumor Necrosis Factor-alpha
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pubmed:year |
1987
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pubmed:articleTitle |
Inhibition by interleukin-1 of the action of erythropoietin on erythroid precursors and its possible role in the pathogenesis of hypoplastic anaemias.
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pubmed:affiliation |
Division of Biology and Medicine, Lawrence Berkeley Laboratory, University of California, Berkeley.
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pubmed:publicationType |
Journal Article
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