Linked Life Data

3498904

Source:http://linkedlifedata.com/resource/pubmed/id/3498904

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6139
pubmed:dateCreated
1987-11-9
pubmed:abstractText
Vaccinia virus recombinants that express cloned genes encoding antigens of unrelated infectious agents, such as hepatitis B virus and human immunodeficiency virus (HIV), provide a new approach to the development of live vaccines. Although there is evidence that genetically engineered vaccinia viruses have reduced pathogenicity a major obstacle to their use as vaccines is that severe complications can occur after vaccination, especially in immunodeficient individuals. We describe here a recombinant vaccinia virus expressing murine interleukin-2 (IL-2) and show that athymic nude mice infected with the recombinant virus resolve the virus infection rapidly whereas mice infected with control virus develop a progressive vaccinal disease. By incorporating the gene for IL-2 in live virus vaccines it may be possible to prevent the severe complications that arise in recipients with an impaired immune system.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0028-0836
pubmed:author
pubmed:issnType
Print
pubmed:volume
329
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
545-6
pubmed:dateRevised
2006-4-21
pubmed:meshHeading
pubmed:articleTitle
Recovery of immunodeficient mice from a vaccinia virus/IL-2 recombinant infection.
pubmed:affiliation
Department of Experimental Pathology, John Curtin School of Medical Research, Australian National University, Canberra.
pubmed:publicationType
Journal Article