Linked Life Data

3498788

Source:http://linkedlifedata.com/resource/pubmed/id/3498788

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1987-11-12
pubmed:abstractText
Bone marrow prothymocytes from me/me and mev/mev mutant mice fail to generate thymocytes in irradiated (600 rad) +/+ wild-type recipients after intravenous injection. However, these same prothymocytes readily generate thymocytes after intrathymic injection. The results of the present study demonstrate that this apparent defect in the thymus-homing capacity of mev/mev prothymocytes can be corrected by mixing irradiated wild-type bone marrow cells with mev/mev bone marrow cells before intravenous injection. However, this defect is not corrected by passage of mev/mev bone marrow cells through the bone marrow of irradiated wild-type recipients. One interpretation of these results is that the maturation of prothymocytes is reversibly arrested in mev/mev mice by a defect in the radiosensitive compartment of the bone marrow microenvironment.
pubmed:grant
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0022-1007
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
166
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1162-7
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1987
pubmed:articleTitle
Defective lymphopoiesis in the bone marrow of motheaten (me/me) and viable motheaten (mev/mev) mutant mice. III. Normal mouse bone marrow cells enable mev/mev prothymocytes to generate thymocytes after intravenous transfer.
pubmed:affiliation
Department of Pathology, School of Medicine, University of Connecticut Health Center, Farmington 06032.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't