Linked Life Data

3498704

Source:http://linkedlifedata.com/resource/pubmed/id/3498704

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1987-11-19
pubmed:abstractText
The classical method of evaluating whether genetic factors are involved in the etiology of a given disease and to what extent is the twin method. However, methodological problems are great, and it is possible only in a few countries to apply this method to multiple sclerosis (MS) research. To draw genetical conclusions it is of fundamental importance that the material should be an unselected, unbiased material derived from a twin population. Another fundamental point is the diagnosis of twin zygosity. In MS research the twin method has been applied by several authors, but a Mendelian mode of inheritance has not been shown to exist. However, an association of MS to the genetic HLA system has been demonstrated, and this suggests that genetical factors are of some importance in the development of MS. Methodological problems are discussed and the most important twin studies in MS, including the Danish twin study.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0392-0461
pubmed:author
pubmed:issnType
Print
pubmed:volume
Suppl 6
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
35-9
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
1987
pubmed:articleTitle
Twin studies in multiple sclerosis.
pubmed:affiliation
Department of Neurology, Roskilde Amssygehus.
pubmed:publicationType
Journal Article