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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
1987-9-2
|
| pubmed:abstractText |
Glucocorticoid-induced enhancement of polyclonal immunoglobulin production of the IgG, A, and M classes by human peripheral blood mononuclear cells has been shown to be dependent on regulatory T-cells. The following in vitro investigation demonstrated an enhancing effect of glucocorticoid on IgE production by mononuclear cells from atopic patients, but not by cells from non-atopic subjects. Augmentation was noted even in cell populations depleted of T cells and monocytes. These observations suggest that the corticosteroid acted directly on an IgE B cell at a late stage of differentiation that was no longer dependent on helper T-cells, although an additional effect on T-suppressor cells was not excluded.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0742-2814
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
8
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
81-4
|
| pubmed:dateRevised |
2007-6-14
|
| pubmed:meshHeading | |
| pubmed:articleTitle |
Glucocorticoid-induced enhancement of IgE synthesis.
|
| pubmed:publicationType |
Journal Article,
In Vitro
|