rdf:type |
|
lifeskim:mentions |
umls-concept:C0021755,
umls-concept:C0021756,
umls-concept:C0030685,
umls-concept:C0052562,
umls-concept:C0065506,
umls-concept:C0085752,
umls-concept:C0163054,
umls-concept:C0391871,
umls-concept:C0680255,
umls-concept:C0687760,
umls-concept:C1280500,
umls-concept:C1283071,
umls-concept:C1533691,
umls-concept:C1963578
|
pubmed:issue |
3
|
pubmed:dateCreated |
1987-8-28
|
pubmed:abstractText |
Adriamycin (ADR), 4-hydroperoxycyclophosphamide (4-OOHCYP) and the new cyclophosphamide derivative AZ 7557 (AZ) were tested for their effects on the release of the Interleukins IL-2 and IL-1 from rat spleen cells and peritoneal exudate macrophages respectively. ADR was found to enhance IL-2 release and less effectively IL-1 release. 4-OOHCYP and AZ were found to inhibit IL-2 release but had no effect on IL-1 production. It is suggested that the modulation of IL-2 levels by these drugs is unlikely to be mediated by their effects on IL-1.
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:issn |
0192-0561
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:volume |
9
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
355-61
|
pubmed:dateRevised |
2006-11-15
|
pubmed:meshHeading |
pubmed-meshheading:3497116-Animals,
pubmed-meshheading:3497116-Antineoplastic Agents,
pubmed-meshheading:3497116-Ascitic Fluid,
pubmed-meshheading:3497116-Cyclophosphamide,
pubmed-meshheading:3497116-Doxorubicin,
pubmed-meshheading:3497116-Interleukin-1,
pubmed-meshheading:3497116-Interleukin-2,
pubmed-meshheading:3497116-Male,
pubmed-meshheading:3497116-Rats,
pubmed-meshheading:3497116-Rats, Inbred Lew,
pubmed-meshheading:3497116-Spleen
|
pubmed:year |
1987
|
pubmed:articleTitle |
Effects of adriamycin, 4-hydroperoxycyclophosphamide and ASTA Z 7557 (INN mafosfamide) on the release of IL-2 and IL-1 in vitro.
|
pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
|