| pubmed-article:3495234 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3495234 | lifeskim:mentions | umls-concept:C0087111 | lld:lifeskim |
| pubmed-article:3495234 | lifeskim:mentions | umls-concept:C0002680 | lld:lifeskim |
| pubmed-article:3495234 | lifeskim:mentions | umls-concept:C0008168 | lld:lifeskim |
| pubmed-article:3495234 | lifeskim:mentions | umls-concept:C0014310 | lld:lifeskim |
| pubmed-article:3495234 | lifeskim:mentions | umls-concept:C0028902 | lld:lifeskim |
| pubmed-article:3495234 | lifeskim:mentions | umls-concept:C0276026 | lld:lifeskim |
| pubmed-article:3495234 | lifeskim:mentions | umls-concept:C0220825 | lld:lifeskim |
| pubmed-article:3495234 | lifeskim:mentions | umls-concept:C1517004 | lld:lifeskim |
| pubmed-article:3495234 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:3495234 | pubmed:dateCreated | 1987-6-8 | lld:pubmed |
| pubmed-article:3495234 | pubmed:abstractText | A murine model of bacteremic Haemophilus influenzae type b pneumonia was used to evaluate the therapeutic efficacies of the quinolone antimicrobial agents enoxacin and ofloxacin compared with those of ampicillin and chloramphenicol. Ampicillin-susceptible (AS) and ampicillin-resistant (AR) challenge strains were employed. Treatment with enoxacin or ofloxacin produced intrapulmonary killing of H. influenzae that was superior to that achieved with ampicillin (P less than 0.01 to P less than 0.001 for both AS and AR strains). Ofloxacin and enoxacin also provided killing greater than that with chloramphenicol for the AS strain (P less than 0.01 to P less than 0.001). For the AR strain, ofloxacin provided killing greater than that obtained with chloramphenicol (P less than 0.001). Survival from AS strain pneumonia was 60% in enoxacin-treated and 78% in ofloxacin-treated animals compared with 41% for chloramphenicol-treated and 23% for ampicillin-treated groups. We conclude that enoxacin and ofloxacin may be effective antimicrobial agents in treating either AS or AR strains causing H. influenzae pneumonia. | lld:pubmed |
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| pubmed-article:3495234 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3495234 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3495234 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:3495234 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3495234 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:3495234 | pubmed:issn | 0066-4804 | lld:pubmed |
| pubmed-article:3495234 | pubmed:author | pubmed-author:PenningtonJ... | lld:pubmed |
| pubmed-article:3495234 | pubmed:author | pubmed-author:BornerKK | lld:pubmed |
| pubmed-article:3495234 | pubmed:author | pubmed-author:KemmerichBB | lld:pubmed |
| pubmed-article:3495234 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3495234 | pubmed:volume | 31 | lld:pubmed |
| pubmed-article:3495234 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3495234 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3495234 | pubmed:pagination | 417-20 | lld:pubmed |
| pubmed-article:3495234 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:3495234 | pubmed:year | 1987 | lld:pubmed |
| pubmed-article:3495234 | pubmed:articleTitle | Comparative evaluation of enoxacin, ofloxacin, ampicillin, and chloramphenicol for treatment of experimental Haemophilus influenzae pneumonia. | lld:pubmed |
| pubmed-article:3495234 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3495234 | pubmed:publicationType | Comparative Study | lld:pubmed |
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