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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1987-6-8
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pubmed:abstractText |
A murine model of bacteremic Haemophilus influenzae type b pneumonia was used to evaluate the therapeutic efficacies of the quinolone antimicrobial agents enoxacin and ofloxacin compared with those of ampicillin and chloramphenicol. Ampicillin-susceptible (AS) and ampicillin-resistant (AR) challenge strains were employed. Treatment with enoxacin or ofloxacin produced intrapulmonary killing of H. influenzae that was superior to that achieved with ampicillin (P less than 0.01 to P less than 0.001 for both AS and AR strains). Ofloxacin and enoxacin also provided killing greater than that with chloramphenicol for the AS strain (P less than 0.01 to P less than 0.001). For the AR strain, ofloxacin provided killing greater than that obtained with chloramphenicol (P less than 0.001). Survival from AS strain pneumonia was 60% in enoxacin-treated and 78% in ofloxacin-treated animals compared with 41% for chloramphenicol-treated and 23% for ampicillin-treated groups. We conclude that enoxacin and ofloxacin may be effective antimicrobial agents in treating either AS or AR strains causing H. influenzae pneumonia.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/3495234-1083200,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3495234-2940970,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3495234-301574,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3495234-304671,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3495234-3159336,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3495234-316308,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3495234-3862361,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3495234-6223577,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3495234-6226241,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3495234-6586712,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3495234-6605104,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3495234-6610002,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3495234-6960805,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3495234-6970414,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3495234-835601
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0066-4804
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
31
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
417-20
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:3495234-Ampicillin,
pubmed-meshheading:3495234-Animals,
pubmed-meshheading:3495234-Anti-Bacterial Agents,
pubmed-meshheading:3495234-Chloramphenicol,
pubmed-meshheading:3495234-Enoxacin,
pubmed-meshheading:3495234-Female,
pubmed-meshheading:3495234-Haemophilus Infections,
pubmed-meshheading:3495234-Haemophilus influenzae,
pubmed-meshheading:3495234-Kinetics,
pubmed-meshheading:3495234-Lung,
pubmed-meshheading:3495234-Male,
pubmed-meshheading:3495234-Mice,
pubmed-meshheading:3495234-Naphthyridines,
pubmed-meshheading:3495234-Ofloxacin,
pubmed-meshheading:3495234-Oxazines,
pubmed-meshheading:3495234-Pneumonia
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pubmed:year |
1987
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pubmed:articleTitle |
Comparative evaluation of enoxacin, ofloxacin, ampicillin, and chloramphenicol for treatment of experimental Haemophilus influenzae pneumonia.
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pubmed:publicationType |
Journal Article,
Comparative Study
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