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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
1987-5-26
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pubmed:abstractText |
Mouse L cell lines have been developed which constitutively express glycoproteins B (gB) and D (gD) of herpes simplex virus type 1. When used to study the immune response of mice to the viral glycoproteins, it was found that both gB and gD induce a delayed type hypersensitivity response and both also induce an antibody response, but only the cell line expressing gD could stimulate the production of neutralizing antibody. Virus-specific cytotoxic T lymphocytes (CTLs) recognized gB expressed by the cell line and this line could also induce CTLs in mice. Recognition of gD by major histocompatibility complex class I restricted CTLs was never seen. Vaccination of mice with the cell lines provided protection from viral challenge and inhibited the establishment of a latent infection, although gD proved to be the better protective immunogen.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0022-1317
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
68 ( Pt 4)
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1103-14
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pubmed:dateRevised |
2008-8-26
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pubmed:meshHeading |
pubmed-meshheading:3494812-Animals,
pubmed-meshheading:3494812-Antibodies, Viral,
pubmed-meshheading:3494812-Base Sequence,
pubmed-meshheading:3494812-Cell Line,
pubmed-meshheading:3494812-Cloning, Molecular,
pubmed-meshheading:3494812-Female,
pubmed-meshheading:3494812-Genes,
pubmed-meshheading:3494812-Hypersensitivity, Delayed,
pubmed-meshheading:3494812-Immunization,
pubmed-meshheading:3494812-L Cells (Cell Line),
pubmed-meshheading:3494812-Lymphocyte Activation,
pubmed-meshheading:3494812-Mice,
pubmed-meshheading:3494812-Mice, Inbred CBA,
pubmed-meshheading:3494812-T-Lymphocytes, Cytotoxic,
pubmed-meshheading:3494812-Viral Envelope Proteins
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pubmed:year |
1987
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pubmed:articleTitle |
Specificity of the immune response of mice to herpes simplex virus glycoproteins B and D constitutively expressed on L cell lines.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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