Linked Life Data

3493814

Source:http://linkedlifedata.com/resource/pubmed/id/3493814

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1987-5-18
pubmed:abstractText
The interaction of alpha-tocopherol (alpha-T) and its synthetic derivative 2,2,5,7,8-pentamethyl-6-hydroxy-chroman (PMC) with cytochrome P-450 system was studied in the rat liver microsomes. Spectral differentiations of type I, increase of NADPH oxidation rate and inhibition of 7-ethoxycoumarin deethylase in microsomes were observed only in the presence of PMC. The results obtained suggest that unlike alpha-T, PMC is effectively bound and metabolized by cytochrome P-450.
pubmed:language
rus
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0365-9615
pubmed:author
pubmed:issnType
Print
pubmed:volume
103
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
304-6
pubmed:dateRevised
2008-10-8
pubmed:meshHeading
pubmed:year
1987
pubmed:articleTitle
[Does alpha-tocopherol interact with the active center of cytochrome P-450 in liver microsomes?].
pubmed:publicationType
Journal Article, Comparative Study, English Abstract