Linked Life Data

3493705

Source:http://linkedlifedata.com/resource/pubmed/id/3493705

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2 Pt 1
pubmed:dateCreated
1987-3-30
pubmed:abstractText
Calcitonin gene-related peptide (CGRP) is a 37-residue peptide present in the central and peripheral nervous system. Based on previous reports of its localization in fibers associated with vascular smooth muscles of vessels and its potent inhibitory effect on acid secretion, we studied the influence of intravenous infusion of rat CGRP on gastric mucosal blood flow. The hydrogen gas-clearance technique was used to measure mucosal blood flow in urethan-anesthetized rats. CGRP infused intravenously in doses of 1 or 10 micrograms X kg-1 X h-1 did not significantly modify basal gastric corpus mucosal blood flow or mean-arterial blood pressure. Gastric acid secretion stimulated by pentagastrin infusion (20 micrograms X kg-1 X h-1) was suppressed by CGRP administration (10 micrograms X kg-1 X h-1), whereas neither gastric corpus mucosal blood flow nor mean arterial blood pressure were significantly changed. These results indicate that CGRP must exert its inhibitory action on gastric acid secretion by a mechanism other than decreasing gastric mucosal blood flow.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0002-9513
pubmed:author
pubmed:issnType
Print
pubmed:volume
252
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
G215-8
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1987
pubmed:articleTitle
Calcitonin gene-related peptide inhibits acid secretion without modifying blood flow.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, U.S. Gov't, Non-P.H.S., Research Support, Non-U.S. Gov't