Linked Life Data

349361

Source:http://linkedlifedata.com/resource/pubmed/id/349361

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1978-7-15
pubmed:abstractText
The state of the major and the minor DNA grooves in purified mono- and oligonucleosomes and in the complexes of DNA with different histones have been studied by means of methylation of DNA with dimethyl sulphate. In nucleosomes histones shielded major groove by 18--20%. This result agrees well with our previous data obtained with chromatin, nuclei and whole cells. Each of the purified histones H2a, H2b, H3 and H4 as well as N-terminal peptides of H4 histone cause relative shielding of the DNA major groove by 15--18% like whole histone does. H1 histone protects neither DNA grooves from methylation. Our results suggest that histones are buried partly in the major groove of DNA in chromatin and purified nucleosomes. The arrangement of histones in the major groove does not depend probably on their specific organization in nucleosomes.
pubmed:language
rus
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0026-8984
pubmed:author
pubmed:issnType
Print
pubmed:volume
12
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
365-71
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:articleTitle
[State of DNA slots in mono- and oligonucleosomes and in DNA complexes with individual histones].
pubmed:publicationType
Journal Article, English Abstract, Historical Article