Linked Life Data

3493522

Source:http://linkedlifedata.com/resource/pubmed/id/3493522

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1987-4-7
pubmed:abstractText
Previously, we demonstrated that both antacids and sucralfate can protect the gastric mucosa against alcohol injury. Since these compounds contain aluminum, we studied whether other aluminum compounds have cytoprotective properties as well. Fasted rats were pretreated intragastrically with A) 0.9% NaCl, B) sucralfate, C) aluminum-magnesium antacid gel, D) Al2(SO4)3, E) Al(OH)3, and 1 h later they received 2 ml 100% ethanol by gavage. The stomach was removed and assessed for injury 3 h after ethanol administration. Control (group A) rats had 39 +/- 3% gross mucosal injury, which was reduced to 5 +/- 1% with sucralfate, 7 +/- 1% with Al2(SO4)3, 12 +/- 2% with Al(OH)3, and 16 +/- 2% with aluminum-magnesium antacid gel pretreatment. Microscopic surface epithelial injury and submucosal edema were seen in all five groups, while deep mucosal necrosis was largely prevented by pretreatment in groups B to E. These findings indicate that aluminum in a wide variety of molecular forms can protect the gastric mucosa against alcohol injury.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0085-5928
pubmed:author
pubmed:issnType
Print
pubmed:volume
125
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
151-5
pubmed:dateRevised
2008-2-13
pubmed:meshHeading
pubmed:year
1986
pubmed:articleTitle
Protection against alcohol-induced gastric mucosal injury by aluminum-containing compounds--sucralfate, antacids, and aluminum sulfate.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't