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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
6110
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pubmed:dateCreated |
1987-4-16
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pubmed:abstractText |
T-cell receptors (TCRs) recognize foreign antigens in the context of major histocompatibility complex (MHC)-encoded cell surface proteins. These receptors are heterogeneous, dimeric glycoproteins composed of disulphide linked alpha- and beta-chains. We analysed the diversity of TCRs in a collection of H-2Kb-restricted, 2,4,6-trinitrophenyl (TNP)-specific (H-2Kb/TNP) cytotoxic T-cell (Tc) clones from C57BL/6 mice. Investigation of the beta-chain messenger RNAs revealed that nearly half of these independent clones expressed an identical beta-chain gene. We show here that almost all the Tc clones expressing the predominant beta-chain gene also express an identical alpha-chain gene. These results show that a strong selective pressure acted on the Tc population, resulting in a skewing of the TCR repertoire for H-2Kb/TNP and in the dominant expression of one TCR with this specificity. Possible explanations for this skewing include antigen-driven clonal expansion and network interactions.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/H-2 Antigens,
http://linkedlifedata.com/resource/pubmed/chemical/Nitrobenzenes,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Antigen, T-Cell,
http://linkedlifedata.com/resource/pubmed/chemical/Trinitrobenzenes
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pubmed:status |
MEDLINE
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pubmed:issn |
0028-0836
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
326
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
307-9
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pubmed:dateRevised |
2003-11-14
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pubmed:meshHeading |
pubmed-meshheading:3493439-Animals,
pubmed-meshheading:3493439-H-2 Antigens,
pubmed-meshheading:3493439-Mice,
pubmed-meshheading:3493439-Nitrobenzenes,
pubmed-meshheading:3493439-RNA, Messenger,
pubmed-meshheading:3493439-Receptors, Antigen, T-Cell,
pubmed-meshheading:3493439-Structure-Activity Relationship,
pubmed-meshheading:3493439-T-Lymphocytes, Cytotoxic,
pubmed-meshheading:3493439-Trinitrobenzenes
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pubmed:articleTitle |
Dominance of one T-cell receptor in the H-2Kb/TNP response.
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pubmed:publicationType |
Journal Article
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