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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
1987-4-1
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pubmed:abstractText |
Local administration of nucleoprotein purified from X31 (H3N2) influenza A virus primed for A virus cross-reactive cytotoxic T cells and resulted in substantial protection (75%) of mice from a lethal challenge with the heterologous mouse-adapted A/PR/8/34 (H1N1) virus. By following the course of a lethal virus challenge we found that nucleoprotein priming did not prevent virus infection but rather aided recovery. Nucleoprotein-primed mice suffered initial symptoms of infection, i.e. weight loss and surface temperature changes, but started to recover after approximately 7 days. We suggest that such heterotypic protection can be attributed to priming of A virus cross-reactive cytotoxic T cells.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0022-1317
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
68 ( Pt 2)
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
433-40
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pubmed:dateRevised |
2006-9-27
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pubmed:meshHeading |
pubmed-meshheading:3493324-Animals,
pubmed-meshheading:3493324-Anorexia,
pubmed-meshheading:3493324-Body Weight,
pubmed-meshheading:3493324-Cross Reactions,
pubmed-meshheading:3493324-Fever,
pubmed-meshheading:3493324-Influenza A virus,
pubmed-meshheading:3493324-Injections, Subcutaneous,
pubmed-meshheading:3493324-Mice,
pubmed-meshheading:3493324-Mice, Inbred BALB C,
pubmed-meshheading:3493324-Nucleoproteins,
pubmed-meshheading:3493324-Orthomyxoviridae Infections,
pubmed-meshheading:3493324-RNA-Binding Proteins,
pubmed-meshheading:3493324-T-Lymphocytes, Cytotoxic,
pubmed-meshheading:3493324-Vaccination,
pubmed-meshheading:3493324-Viral Core Proteins,
pubmed-meshheading:3493324-Viral Proteins,
pubmed-meshheading:3493324-Viral Vaccines
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pubmed:year |
1987
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pubmed:articleTitle |
Purified influenza virus nucleoprotein protects mice from lethal infection.
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pubmed:publicationType |
Journal Article
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