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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
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pubmed:dateCreated |
1987-4-21
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pubmed:abstractText |
An influenza virus-specific HLA class II-restricted human T4+ clone (Ij) allows us to define a new functional supertypic HLA class II specificity shared by three different haplotypes. Influenza A virus-infected antigen-presenting cells of these three haplotypes, HLA-DR2 short, DRw11, and DRw13, are able to stimulate Ij cells. The same precise viral specificity is seen in all three cases. Proliferation inhibition experiments using HLA-specific monoclonal antibodies demonstrate that HLA-DR products are involved in all cases. However, according to the DR specificity of the antigen-presenting cell, differential blockings by a series of DR-specific monoclonal antibodies suggest that the functional epitope is shared by different HLA-DR molecules. This is confirmed by two-dimensional gel analysis of the HLA-DR beta chains expressed in the three haplotypes.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:issn |
0093-7711
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
25
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
84-90
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pubmed:dateRevised |
2005-11-22
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pubmed:meshHeading |
pubmed-meshheading:3493215-Antigen-Presenting Cells,
pubmed-meshheading:3493215-Clone Cells,
pubmed-meshheading:3493215-HLA-D Antigens,
pubmed-meshheading:3493215-HLA-DR Antigens,
pubmed-meshheading:3493215-Haplotypes,
pubmed-meshheading:3493215-Humans,
pubmed-meshheading:3493215-Influenza A virus,
pubmed-meshheading:3493215-Isoelectric Point,
pubmed-meshheading:3493215-Lymphocyte Activation,
pubmed-meshheading:3493215-Lymphocyte Cooperation,
pubmed-meshheading:3493215-Molecular Weight,
pubmed-meshheading:3493215-Polymorphism, Genetic,
pubmed-meshheading:3493215-T-Lymphocytes
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pubmed:year |
1987
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pubmed:articleTitle |
An antiviral T-cell clone defines a functional supertypic specificity shared by different HLA-DR molecules from DR2-short, DRw11, and DRw13 haplotypes.
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pubmed:publicationType |
Journal Article
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