rdf:type |
|
lifeskim:mentions |
|
pubmed:issue |
12
|
pubmed:dateCreated |
1987-3-30
|
pubmed:abstractText |
CH31 and CH33 are B cell lymphomas whose growth in vitro is inhibited by anti-Ig reagents, including both polyclonal and monoclonal anti-mu antibodies, and an anti-idiotype antiserum. Antibodies against class I or class II major histocompatibility complex antigens do not affect the growth of these cells. Inhibition is dependent on surface Ig cross-linking and does not require ligand binding to Fc receptors. Interestingly, the inhibition of growth by anti-mu is reversed in CH31 (but not CH33) by E. coli lipopolysaccharide. These lymphomas should provide excellent models to study the mechanisms of growth inhibition mediated by surface Ig cross-linking and the pathways of its reversal.
|
pubmed:grant |
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Dec
|
pubmed:issn |
0014-2980
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:volume |
16
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
1577-81
|
pubmed:dateRevised |
2007-11-15
|
pubmed:meshHeading |
pubmed-meshheading:3493148-Animals,
pubmed-meshheading:3493148-Antibodies, Anti-Idiotypic,
pubmed-meshheading:3493148-B-Lymphocytes,
pubmed-meshheading:3493148-Immune Tolerance,
pubmed-meshheading:3493148-Interphase,
pubmed-meshheading:3493148-Kinetics,
pubmed-meshheading:3493148-Lipopolysaccharides,
pubmed-meshheading:3493148-Lymphocyte Activation,
pubmed-meshheading:3493148-Lymphoma,
pubmed-meshheading:3493148-Mice,
pubmed-meshheading:3493148-Protein Kinase C,
pubmed-meshheading:3493148-Rabbits,
pubmed-meshheading:3493148-Receptors, Antigen, B-Cell,
pubmed-meshheading:3493148-Receptors, Fc
|
pubmed:year |
1986
|
pubmed:articleTitle |
Lymphoma models for B cell activation and tolerance. IV. Growth inhibition by anti-Ig of CH31 and CH33 B lymphoma cells.
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|