Switch to
Predicate | Object |
---|---|
rdf:type | |
lifeskim:mentions | |
pubmed:issue |
5
|
pubmed:dateCreated |
1987-3-30
|
pubmed:abstractText |
An immunotoxin composed of an antibody to the human transferrin receptor (454A12) and ricin A chain (RTA) was shown to inhibit the growth of NIH:OVCAR-3 tumors in a nude mouse model of human ovarian cancer. Inhibition of tumor growth by 454A12-RTA was related to the dose administered. The antitumor activity of the immunotoxin was blocked by coinjection of excess antibody with immunotoxin. An immunotoxin made using 454A12 and recombinant ricin A chain (rRTA) had an activity similar to that made with native RTA. The administration of 10 micrograms or greater of the immunotoxin 454A12-RTA/rRTA had significant antitumor activity. The injection of 30 micrograms of an irrelevant immunotoxin, MOPC21-RTA, or 30 to 500 micrograms of the 454A12 antibody had no antitumor activity.
|
pubmed:language |
eng
|
pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
Mar
|
pubmed:issn |
0008-5472
|
pubmed:author | |
pubmed:issnType |
Print
|
pubmed:day |
1
|
pubmed:volume |
47
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
1407-10
|
pubmed:dateRevised |
2004-11-17
|
pubmed:meshHeading |
pubmed-meshheading:3493065-Animals,
pubmed-meshheading:3493065-Cell Line,
pubmed-meshheading:3493065-Dose-Response Relationship, Drug,
pubmed-meshheading:3493065-Female,
pubmed-meshheading:3493065-Humans,
pubmed-meshheading:3493065-Immunotoxins,
pubmed-meshheading:3493065-Mice,
pubmed-meshheading:3493065-Mice, Nude,
pubmed-meshheading:3493065-Neoplasm Invasiveness,
pubmed-meshheading:3493065-Neoplasm Transplantation,
pubmed-meshheading:3493065-Ovarian Neoplasms,
pubmed-meshheading:3493065-Receptors, Transferrin,
pubmed-meshheading:3493065-Ricin,
pubmed-meshheading:3493065-Transplantation, Heterologous
|
pubmed:year |
1987
|
pubmed:articleTitle |
Antitumor activity of an immunotoxin in a nude mouse model of human ovarian cancer.
|
pubmed:publicationType |
Journal Article
|