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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:dateCreated |
1987-3-5
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pubmed:abstractText |
The human major histocompatibility complex (MHC)-linked genes C2,BF,C4A,C4B occur in populations and segregate in families as single genetic units or complotypes. Analysis for significant three-point linkage disequilibrium between HLA-B, DR and complotype on normal caucasian chromosomes 6p yields about a dozen haplotypes that account for most of the known HLA-B/HLA-DR linkage disequilibrium pairs previously noted in normal caucasian populations. We refer to the HLA-B/DR/complotype sets with significant linkage disequilibrium as extended haplotypes since they often show limited variation at other MHC-linked loci. From the study of MHC haplotypes in 21-hydroxylase deficiency, C2 deficiency and type 1 diabetes, it is becoming apparent that it is extended haplotypes rather than their individual alleles that are markers for these MHC-associated diseases.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:issn |
0067-8694
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
51
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
19-28
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:3493006-Adrenal Hyperplasia, Congenital,
pubmed-meshheading:3493006-Alleles,
pubmed-meshheading:3493006-Complement C2,
pubmed-meshheading:3493006-Complement System Proteins,
pubmed-meshheading:3493006-Diabetes Mellitus, Type 1,
pubmed-meshheading:3493006-European Continental Ancestry Group,
pubmed-meshheading:3493006-Genetic Linkage,
pubmed-meshheading:3493006-Humans,
pubmed-meshheading:3493006-Major Histocompatibility Complex
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pubmed:year |
1986
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pubmed:articleTitle |
Complement genes of the major histocompatibility complex (complotypes), extended haplotypes and disease markers.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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