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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
1987-2-25
|
| pubmed:abstractText |
Thirteen patients underwent electrophysiologic evaluation for recurrent supraventricular tachycardia (SVT). The effects of intravenous bepridil (4 mg/kg) were evaluated during the initial study in 5 patients, and 12 patients underwent repeat study 7 to 10 days later taking oral bepridil, 300 to 400 mg/day. Intravenous bepridil increased the pacing cycle length inducing atrioventricular (AV) (276 +/- 43 vs 334 +/- 31 ms, p less than 0.01) and ventriculoatrial (VA) block (268 +/- 34 vs 310 +/- 35 ms, p less than 0.001), the retrograde refractory period of the accessory pathway (251 +/- 17 vs 295 +/- 25 ms, p less than 0.05) and the ventricular refractory period (216 +/- 17 vs 226 +/- 11 ms, p less than 0.05), and prevented induction of sustained SVT in 3 patients. Oral bepridil increased the sinus cycle length (723 +/- 64 vs 800 +/- 118 ms, p less than 0.05), corrected QT (403 +/- 14 vs 431 +/- 21 ms, p less than 0.05) and the pacing cycle inducing AV (288 +/- 63 vs 353 +/- 78 ms, p less than 0.01) and VA block (271 +/- 31 vs 408 +/- 124 ms, p less than 0.01). It prolonged the refractory period of the atrium (195 +/- 29 vs 233 +/- 36 ms, p less than 0.05), AV node (264 +/- 35 vs 303 +/- 22 ms, p less than 0.05), ventricle (221 +/- 16 vs 245 +/- 21 ms, p less than 0.01), accessory pathway in the AV (290 +/- 47 vs 329 +/- 54 ms, p less than 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jan
|
| pubmed:issn |
0002-9149
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
1
|
| pubmed:volume |
59
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
89-92
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:3492906-Administration, Oral,
pubmed-meshheading:3492906-Adult,
pubmed-meshheading:3492906-Bepridil,
pubmed-meshheading:3492906-Electrophysiology,
pubmed-meshheading:3492906-Female,
pubmed-meshheading:3492906-Follow-Up Studies,
pubmed-meshheading:3492906-Humans,
pubmed-meshheading:3492906-Injections, Intravenous,
pubmed-meshheading:3492906-Male,
pubmed-meshheading:3492906-Middle Aged,
pubmed-meshheading:3492906-Pyrrolidines,
pubmed-meshheading:3492906-Recurrence,
pubmed-meshheading:3492906-Tachycardia,
pubmed-meshheading:3492906-Time Factors
|
| pubmed:year |
1987
|
| pubmed:articleTitle |
Electrophysiologic effects and long-term efficacy of bepridil for recurrent supraventricular tachycardias.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|