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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
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pubmed:dateCreated |
1987-3-2
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pubmed:abstractText |
Although the existence of autoreactive T cells has been widely reported in mice and in guinea pigs, a similar phenomenon is poorly documented in man. Here we report the study of three human autoreactive T cell clones isolated during immunization of HLA-DRw13 donors either against influenza A/Texas virus or against allogeneic cells. These clones are specific for autologous HLA-class II specificities either common to all HLA-DRw13 molecules or restricted to the HLA-DR products specific for the DW19 subtype of HLA-DRw13. They are also cytotoxic and they have the same specificity when tested for lytic activity or in proliferation assays. Furthermore, they are also able to help autologous B cells to polyclonally produce Ig. The possible implication of such clones in regulatory mechanisms involving HLA-class II molecules is discussed.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
AIM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0022-1767
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
138
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
674-9
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:3492528-Adult,
pubmed-meshheading:3492528-Antibodies, Monoclonal,
pubmed-meshheading:3492528-Antigens,
pubmed-meshheading:3492528-B-Lymphocytes,
pubmed-meshheading:3492528-Clone Cells,
pubmed-meshheading:3492528-Cytotoxicity, Immunologic,
pubmed-meshheading:3492528-HLA-D Antigens,
pubmed-meshheading:3492528-HLA-DR Antigens,
pubmed-meshheading:3492528-Humans,
pubmed-meshheading:3492528-Influenza A virus,
pubmed-meshheading:3492528-Lymphocyte Activation,
pubmed-meshheading:3492528-T-Lymphocytes
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pubmed:year |
1987
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pubmed:articleTitle |
Autoreactive T cell clones of MHC class II specificities are produced during responses against foreign antigens in man.
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pubmed:publicationType |
Journal Article
|