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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1987-1-28
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pubmed:abstractText |
Lymphoid tissue in formalin fixed and snap frozen human fetal ileum has been studied using immunohistochemistry. At 11 weeks gestation clusters of cells expressing CD4 (leu-3a positive) are present in fetal ileum but these do not express CD3 (UCHT1 negative) and are probably macrophages. Aggregates of lymphoid tissue are apparent from 14 weeks gestation which contain T cells of helper/inducer and suppressor/cytotoxic phenotype. Both B and T cells are present at 16 weeks but with no cellular zonation. By 19 weeks, distinct follicles of B cells are present surrounded by T cells of helper/inducer and suppressor/cytotoxic phenotype. Follicular dendritic cells are also present within the B cell areas. The B cells at this age express surface IgM and IgD, C3b- and C3d-receptors. They also express the antigen CD5 which has been shown by others to be present on some fetal B cells but which is almost exclusively associated with T cells in the adult. HLA-D region antigens are present on apparently all of the cells within the fetal lymphoid follicles. The antigen on activated B cells, CD23 (recognized by MHM6), was present on some cells scattered within the B cell follicle. This is indicative of antigen independent B cell proliferation.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/3491695-13695582,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3491695-18668776,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3491695-378907,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3491695-3871452,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3491695-6163824,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3491695-6282762,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3491695-6306100,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3491695-6338047,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3491695-6355845,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3491695-6368248,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3491695-6403355,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3491695-6408171,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3491695-6420166,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3491695-6454755,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3491695-6479906,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3491695-6756733,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3491695-6788570,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3491695-7028866,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3491695-7044948
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0009-9104
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
64
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
536-43
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
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pubmed:year |
1986
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pubmed:articleTitle |
The development of gut associated lymphoid tissue in the terminal ileum of fetal human intestine.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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