Linked Life Data

3491251

Source:http://linkedlifedata.com/resource/pubmed/id/3491251

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1987-1-15
pubmed:abstractText
The growth factor-dependent, non-leukemogenic cell line FDC-P1, was converted to an interleukin-3 (IL-3) producing leukemogenic cell line using a retroviral expression vector carrying the IL-3 gene. The new cell line, FDC-P1-IL3 proliferated independently of exogenous IL-3 and its proliferation was inhibited by anti IL-3 antisera. This inhibition could be overcome by addition of GM-CSF to the cultures. The data indicate that insertion of the retroviral expression vector into the genome of FDC-P1 cells has established an autocrine loop involving constitutive secretion of IL-3 and that such a loop can play an important role in leukemogenesis.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0277-6766
pubmed:author
pubmed:issnType
Print
pubmed:volume
5
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
249-54
pubmed:dateRevised
2006-4-21
pubmed:meshHeading
pubmed:year
1986
pubmed:articleTitle
Generation of an autocrine leukaemia using a retroviral expression vector carrying the interleukin-3 gene.
pubmed:publicationType
Journal Article