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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
11
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pubmed:dateCreated |
1986-12-24
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pubmed:databankReference | |
pubmed:abstractText |
A human interleukin 1 beta (IL 1 beta) cDNA probe was utilized to identify a homologous murine cDNA clone. The murine cDNA encodes a 269-residue protein which is 67% homologous to human IL 1 beta. The murine sequence was engineered for expression in mammalian cells and directs the synthesis of biologically active IL 1. This protein, termed murine IL 1 beta, is only 22% homologous with the previously described murine IL 1 sequence. Both IL 1 alpha and IL 1 beta are encoded by single genes, but IL 1 beta mRNA is about fivefold more abundant in a stimulated macrophage cell line.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
AIM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0022-1767
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
137
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3644-8
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pubmed:dateRevised |
2003-11-14
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pubmed:meshHeading |
pubmed-meshheading:3491144-Amino Acid Sequence,
pubmed-meshheading:3491144-Animals,
pubmed-meshheading:3491144-Base Sequence,
pubmed-meshheading:3491144-Cells, Cultured,
pubmed-meshheading:3491144-Cercopithecus aethiops,
pubmed-meshheading:3491144-Cloning, Molecular,
pubmed-meshheading:3491144-DNA,
pubmed-meshheading:3491144-Gene Expression Regulation,
pubmed-meshheading:3491144-Interleukin-1,
pubmed-meshheading:3491144-Mice,
pubmed-meshheading:3491144-RNA, Messenger
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pubmed:year |
1986
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pubmed:articleTitle |
Two interleukin 1 genes in the mouse: cloning and expression of the cDNA for murine interleukin 1 beta.
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pubmed:publicationType |
Journal Article
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