Linked Life Data

3491053

Source:http://linkedlifedata.com/resource/pubmed/id/3491053

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1987-1-6
pubmed:abstractText
We immunized rabbits with human (h) or bovine (b) thyroid-stimulating hormone (TSH), hTSH beta chains or human serum albumin. Serum from the rabbits was then assayed for thyroid-stimulating activity, using the thyroid-cell bioassay. Anti-idiotypic antibodies (anti-ID) to monoclonal anti-TSH were detected in these rabbit antisera after removal of rheumatoid factor by absorption with IgG. Anti-ID activity was detected in the serum of the rabbits immunized with bovine TSH. Thyroid-stimulating antibody (TSI) activity, too, was most prominent in the sera obtained from bTSH-immunized rabbits. Anti-ID activity seemed to arise sooner than did TSI, but both tended to peak 3 months after an initial series of immunizations. Since thyroid-stimulating immunoglobulins can develop following TSH immunization of rabbits, it is possible that a similar immunopathogenesis may be responsible for some instances of Graves' hyperthyroidism.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0020-5915
pubmed:author
pubmed:issnType
Print
pubmed:volume
81
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
351-6
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1986
pubmed:articleTitle
Studies on auto-anti-idiotypic thyroid-stimulating antibodies.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, U.S. Gov't, Non-P.H.S.