Linked Life Data

3490989

Source:http://linkedlifedata.com/resource/pubmed/id/3490989

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11
pubmed:dateCreated
1987-1-15
pubmed:abstractText
Erythropoietin-like activity (EpLA) is one of several hematopoietic growth factors found in spleen cell-conditioned medium. Conditioned media obtained from both dissociated tissues and cloned cell lines were examined in order to define the cellular source of EpLA. The growth factor was only found in supernatants of tissues that contained T-lymphocytes. An examination of media conditioned by cloned cell lines representative of the major cell types in spleen (T- and B-lymphocytes, macrophages) confirmed the association between T cells and EpLA production. Limiting dilution analyses established that normal T-lymphocyte clones produced EpLA, but this property was not correlated with a specific functional T-cell subset. On stimulation with PMA, the T-cell lymphoma cell line, EL-4, proved to be the most potent producer of EpLA found to date.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0301-472X
pubmed:author
pubmed:issnType
Print
pubmed:volume
14
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1006-10
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1986
pubmed:articleTitle
Cells of T-lymphocyte origin produce an erythropoietin-like growth factor.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't