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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
11
|
pubmed:dateCreated |
1987-1-20
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pubmed:abstractText |
Culture supernatants from a myelomonocytic cell line (M20) were found to inhibit interleukin 1 (IL 1) activity in vitro. The factor, isolated from these supernatants, inhibited augmentation of phytohemagglutinin response of mouse thymus cells induced by IL 1 derived from several established cell lines. Various IL 1-dependent activities such as lymphocyte and fibroblast proliferation in vitro were also inhibited by the factor. The factor did not inhibit IL 2-induced or other proliferative responses not related to IL 1. Preliminary biochemical characterization of the factor indicated that the activity resides in a protein with a molecular mass of 52 kDa.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0014-2980
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
16
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1449-52
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:3490987-Cell Division,
pubmed-meshheading:3490987-Cell Line,
pubmed-meshheading:3490987-Depression, Chemical,
pubmed-meshheading:3490987-Fibroblasts,
pubmed-meshheading:3490987-Humans,
pubmed-meshheading:3490987-Interleukin-1,
pubmed-meshheading:3490987-Interleukin-2,
pubmed-meshheading:3490987-Leukemia, Myeloid,
pubmed-meshheading:3490987-Lymphocyte Activation,
pubmed-meshheading:3490987-Lymphokines,
pubmed-meshheading:3490987-Monocytes,
pubmed-meshheading:3490987-Phytohemagglutinins
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pubmed:year |
1986
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pubmed:articleTitle |
Interleukin 1 inhibitory activity secreted by a human myelomonocytic cell line (M20).
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|