Linked Life Data

3490466

Source:http://linkedlifedata.com/resource/pubmed/id/3490466

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1986-12-4
pubmed:abstractText
A total of 78 strains of Bacteroides was freshly isolated from clinical specimens; 60 of the strains were identified as B. fragilis and 16 as B. thetaiotaomicron. Overall, imipenem and the combination of benzylpenicillin and clavulanic acid were found to be considerably more active than cefoxitin or latamoxef (moxalactam) against these strains. Nearly all the strains exhibited weak beta-lactamase activity and 13 were judged to produce elevated levels of enzyme. These 13 strains fell into three groups: four strains that produced enzymes of low specific activity which were very susceptible to beta-lactamase inhibitors; three strains that produced enzymes of intermediate specific activity which hydrolysed cefoxitin and latamoxef at a variable rate; two of these enzymes rapidly inactivated imipenem and were insusceptible to beta-lactamase inhibitors; six strains that produced enzymes of high specific activity which were susceptible to beta-lactamase inhibitors; these strains did not inactivate beta-lactamase-stable beta-lactam antibiotics, but two of the strains nonetheless exhibited reduced susceptibility to latamoxef and imipenem.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0305-7453
pubmed:author
pubmed:issnType
Print
pubmed:volume
18
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
325-33
pubmed:dateRevised
2004-11-18
pubmed:meshHeading
pubmed:year
1986
pubmed:articleTitle
Characterization of beta-lactamases in clinical isolates of Bacteroides.
pubmed:publicationType
Journal Article