| pubmed-article:3490281 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3490281 | lifeskim:mentions | umls-concept:C0010762 | lld:lifeskim |
| pubmed-article:3490281 | lifeskim:mentions | umls-concept:C0376286 | lld:lifeskim |
| pubmed-article:3490281 | lifeskim:mentions | umls-concept:C0969677 | lld:lifeskim |
| pubmed-article:3490281 | lifeskim:mentions | umls-concept:C1280519 | lld:lifeskim |
| pubmed-article:3490281 | lifeskim:mentions | umls-concept:C0441712 | lld:lifeskim |
| pubmed-article:3490281 | pubmed:issue | 9 | lld:pubmed |
| pubmed-article:3490281 | pubmed:dateCreated | 1986-12-12 | lld:pubmed |
| pubmed-article:3490281 | pubmed:abstractText | The efficiency of alpha-tocopherol as a 7-etoxycumarine deethylase protector in rat liver microsomes damaged by phospholipase A2 at various levels of vitamin E was studied. No selective damage of cytochrome P-450 isoforms possessing a catalytic activity towards 7-etoxycumarine under vitamin E deficiency was observed. Phospholipase A2 decreased the deethylase activity of cytochrome P-450, the efficiency of the damaging action being dependent on vitamin E content in the liver. Exogenous alpha-tocopherol exerts an antiphospholipase effect and protects 7-etoxycumarine deethylase; the protective action is inversely proportional to vitamin E level in the liver. Under normal conditions the damaging effect of phospholipase A2 on cytochrome P-450 is mainly provided for by lysophospholipids, while under vitamin E deficiency both lysophospholipids and free fatty acids exert a damaging action. A possible mechanism of the stabilizing effect of alpha-tocopherol may consist in the interaction of the chromanol nucleus in the vitamin E molecyule both with lysophospholipids and with free fatty acids. | lld:pubmed |
| pubmed-article:3490281 | pubmed:language | rus | lld:pubmed |
| pubmed-article:3490281 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3490281 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:3490281 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3490281 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3490281 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3490281 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3490281 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3490281 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3490281 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3490281 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3490281 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3490281 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3490281 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:3490281 | pubmed:issn | 0320-9725 | lld:pubmed |
| pubmed-article:3490281 | pubmed:author | pubmed-author:VinesR HRH | lld:pubmed |
| pubmed-article:3490281 | pubmed:author | pubmed-author:KozlovIu PIuP | lld:pubmed |
| pubmed-article:3490281 | pubmed:author | pubmed-author:ArkhipenkoIu... | lld:pubmed |
| pubmed-article:3490281 | pubmed:author | pubmed-author:NovikovK NKN | lld:pubmed |
| pubmed-article:3490281 | pubmed:author | pubmed-author:SkrypinV IVI | lld:pubmed |
| pubmed-article:3490281 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3490281 | pubmed:volume | 51 | lld:pubmed |
| pubmed-article:3490281 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3490281 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3490281 | pubmed:pagination | 1549-54 | lld:pubmed |
| pubmed-article:3490281 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
| pubmed-article:3490281 | pubmed:meshHeading | pubmed-meshheading:3490281-... | lld:pubmed |
| pubmed-article:3490281 | pubmed:meshHeading | pubmed-meshheading:3490281-... | lld:pubmed |
| pubmed-article:3490281 | pubmed:meshHeading | pubmed-meshheading:3490281-... | lld:pubmed |
| pubmed-article:3490281 | pubmed:meshHeading | pubmed-meshheading:3490281-... | lld:pubmed |
| pubmed-article:3490281 | pubmed:meshHeading | pubmed-meshheading:3490281-... | lld:pubmed |
| pubmed-article:3490281 | pubmed:meshHeading | pubmed-meshheading:3490281-... | lld:pubmed |
| pubmed-article:3490281 | pubmed:meshHeading | pubmed-meshheading:3490281-... | lld:pubmed |
| pubmed-article:3490281 | pubmed:meshHeading | pubmed-meshheading:3490281-... | lld:pubmed |
| pubmed-article:3490281 | pubmed:meshHeading | pubmed-meshheading:3490281-... | lld:pubmed |
| pubmed-article:3490281 | pubmed:meshHeading | pubmed-meshheading:3490281-... | lld:pubmed |
| pubmed-article:3490281 | pubmed:meshHeading | pubmed-meshheading:3490281-... | lld:pubmed |
| pubmed-article:3490281 | pubmed:meshHeading | pubmed-meshheading:3490281-... | lld:pubmed |
| pubmed-article:3490281 | pubmed:meshHeading | pubmed-meshheading:3490281-... | lld:pubmed |
| pubmed-article:3490281 | pubmed:meshHeading | pubmed-meshheading:3490281-... | lld:pubmed |
| pubmed-article:3490281 | pubmed:meshHeading | pubmed-meshheading:3490281-... | lld:pubmed |
| pubmed-article:3490281 | pubmed:year | 1986 | lld:pubmed |
| pubmed-article:3490281 | pubmed:articleTitle | [Non-antioxidative mechanism of cytochrome P-450 stabilization by alpha-tocopherol: the effectiveness in avitaminosis E]. | lld:pubmed |
| pubmed-article:3490281 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3490281 | pubmed:publicationType | English Abstract | lld:pubmed |
