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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
1986-12-12
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pubmed:abstractText |
The efficiency of alpha-tocopherol as a 7-etoxycumarine deethylase protector in rat liver microsomes damaged by phospholipase A2 at various levels of vitamin E was studied. No selective damage of cytochrome P-450 isoforms possessing a catalytic activity towards 7-etoxycumarine under vitamin E deficiency was observed. Phospholipase A2 decreased the deethylase activity of cytochrome P-450, the efficiency of the damaging action being dependent on vitamin E content in the liver. Exogenous alpha-tocopherol exerts an antiphospholipase effect and protects 7-etoxycumarine deethylase; the protective action is inversely proportional to vitamin E level in the liver. Under normal conditions the damaging effect of phospholipase A2 on cytochrome P-450 is mainly provided for by lysophospholipids, while under vitamin E deficiency both lysophospholipids and free fatty acids exert a damaging action. A possible mechanism of the stabilizing effect of alpha-tocopherol may consist in the interaction of the chromanol nucleus in the vitamin E molecyule both with lysophospholipids and with free fatty acids.
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pubmed:language |
rus
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0320-9725
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
51
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1549-54
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:3490281-7-Alkoxycoumarin O-Dealkylase,
pubmed-meshheading:3490281-Animals,
pubmed-meshheading:3490281-Coumarins,
pubmed-meshheading:3490281-Cytochrome P-450 Enzyme System,
pubmed-meshheading:3490281-Hydrolysis,
pubmed-meshheading:3490281-Male,
pubmed-meshheading:3490281-Microsomes, Liver,
pubmed-meshheading:3490281-Oxygenases,
pubmed-meshheading:3490281-Phospholipases A,
pubmed-meshheading:3490281-Phospholipases A2,
pubmed-meshheading:3490281-Phospholipids,
pubmed-meshheading:3490281-Rats,
pubmed-meshheading:3490281-Rats, Inbred Strains,
pubmed-meshheading:3490281-Vitamin E,
pubmed-meshheading:3490281-Vitamin E Deficiency
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pubmed:year |
1986
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pubmed:articleTitle |
[Non-antioxidative mechanism of cytochrome P-450 stabilization by alpha-tocopherol: the effectiveness in avitaminosis E].
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pubmed:publicationType |
Journal Article,
English Abstract
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