Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
1986-10-31
|
| pubmed:abstractText |
Cultured human endothelial cells produce increased levels of PA-I when stimulated with IL-1. The stimulatory effect was elicited by both alpha (pI 5) and beta (pI 7) IL-1 molecules. The effect was both dose and time-dependent, plateau reached after 8 h. The PA-I measured in cell extracts was SDS-resistant with an apparent m.w. of 53 Kd and inhibited both tissue-type plasminogen activator (t-PA) and urokinase (UK). No change in t-PA antigen level was detected with any of the IL-1 preparations tested.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Sep
|
| pubmed:issn |
0006-291X
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
14
|
| pubmed:volume |
139
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
720-7
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:3490260-Cells, Cultured,
pubmed-meshheading:3490260-Dose-Response Relationship, Drug,
pubmed-meshheading:3490260-Endothelium,
pubmed-meshheading:3490260-Glycoproteins,
pubmed-meshheading:3490260-Humans,
pubmed-meshheading:3490260-Interleukin-1,
pubmed-meshheading:3490260-Molecular Weight,
pubmed-meshheading:3490260-Plasminogen Inactivators,
pubmed-meshheading:3490260-Sodium Dodecyl Sulfate,
pubmed-meshheading:3490260-Time Factors
|
| pubmed:year |
1986
|
| pubmed:articleTitle |
Enhancement by interleukin-1 (IL-1) of plasminogen activator inhibitor (PA-I) activity in cultured human endothelial cells.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|