Linked Life Data

3489303

Source:http://linkedlifedata.com/resource/pubmed/id/3489303

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1986-10-3
pubmed:abstractText
Contrary to the transitory, enlarged thymic shadow commonly observed in babies, tumor-like Massive Thymic Hyperplasia (MTH) is seldom encountered in infancy and even more rarely in children over 4 years. We present three cases of MTH affecting 10, 5 and 11 years old girls in whom the tremendous enlargement of the thymus (3 to 4 times the normal) led to consideration of a diagnosis of a genuine tumoral process and to either biopsy or surgical removal of the thymic mass. Optical histological examination showed a perfectly normal thymic tissue and indicated that MTH was linked with a simple and homogeneous hyperplasia of the lymphoid cells. Using the dot-like acid alpha-naphtyl acetate esterase (ANAE) as a marker of mature T cells, quantitative and comparative cytoenzymatic studies revealed a definite reduction of ANAE +, mature T cells in the cortical and medullary areas in MTH (p less than or equal to 0.001). These findings suggest that MTH represents an intrathymic accumulation of immature T cells, a condition which may express a failure of cell differentiation perhaps connected with some thymic hormonal insufficiency.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0165-6090
pubmed:author
pubmed:issnType
Print
pubmed:volume
8
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
177-86
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
1986
pubmed:articleTitle
Tumor-like massive thymic hyperplasia in childhood: a possible defect of T-cell maturation, histological and cytoenzymatic studies of three cases.
pubmed:publicationType
Journal Article, Case Reports