Linked Life Data

3488226

Source:http://linkedlifedata.com/resource/pubmed/id/3488226

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
1986-9-17
pubmed:abstractText
We have previously demonstrated the ability of soluble factors derived from cultured murine and human bone marrow supernatants to modulate a variety of lymphoid functions, including DNA synthesis. In the present report, we show that human marrow supernatants contain a suppressor factor (BSF) that suppresses T-lymphoid colony formation, and an augmenting factor (BEF) that enhances T-colony growth. BSF suppression exhibits no tissue specificity, affecting marrow-derived and peripheral T colonies similarly. The suppressive activity occurs prior to mitogenic activation by TCGF. In contrast, a preferential augmentation of the size and number of marrow-derived T-cell colonies, as compared to peripheral T-cell colonies, was observed in the presence of BEF. BEF required prior mitogen activation of the colony inocula to effect colony enhancement. In addition, the response to BEF was greater for E- than for E+ colony-forming cells, indicating the target of BEF activity to be an early T cell. The active subfraction of BEF with colony-enhancing activity was found to be between 8000 and 30,000 daltons.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0301-472X
pubmed:author
pubmed:issnType
Print
pubmed:volume
14
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
648-53
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
1986
pubmed:articleTitle
Regulation of lymphoid colony growth by factors derived from human bone marrow.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't