| pubmed-article:3487021 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3487021 | lifeskim:mentions | umls-concept:C0227525 | lld:lifeskim |
| pubmed-article:3487021 | lifeskim:mentions | umls-concept:C0241910 | lld:lifeskim |
| pubmed-article:3487021 | lifeskim:mentions | umls-concept:C0520463 | lld:lifeskim |
| pubmed-article:3487021 | lifeskim:mentions | umls-concept:C0312740 | lld:lifeskim |
| pubmed-article:3487021 | lifeskim:mentions | umls-concept:C0301896 | lld:lifeskim |
| pubmed-article:3487021 | lifeskim:mentions | umls-concept:C0439859 | lld:lifeskim |
| pubmed-article:3487021 | lifeskim:mentions | umls-concept:C1880022 | lld:lifeskim |
| pubmed-article:3487021 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:3487021 | pubmed:dateCreated | 1986-6-27 | lld:pubmed |
| pubmed-article:3487021 | pubmed:abstractText | Peripheral blood lymphocyte subsets involved in cytotoxicity to autologous hepatocytes have been characterized by isolation on antibody-coated Petri dishes in autoimmune and HBsAg-positive chronic active hepatitis (CAH). In autoimmune CAH and in HBsAg-positive CAH without HBcAg in liver tissue, cytotoxicity is sustained by non-T lymphocytes and is confined to M1-positive cells bearing Fc receptors: M1 cytotoxicity inhibition by adding aggregated IgG suggests that these cells are responsible for an antibody-dependent cell-mediated mechanism (ADCC). Moreover, when T-enriched fractions were separated in T4, T8 and 5/9 positive subsets, only the first one showed a significant cytotoxicity: T4 positive cells might act as cytotoxic T cells or might be involved in delayed type hypersensitivity (DTH) reactions. Cytotoxic T lymphocytes in HBsAg-positive CAH with HBcAg in liver tissue are confined in T8 positive subset, while helper/inducer T cells (T4 positive or 5/9 positive) seem to play an important role only in the induction of cell-mediated injury against hepatocytes. The inhibition of T cell-cytotoxicity by preincubating liver cells with monoclonal antibody (Mab) anti-HLA AB and not with Mab anti-HLA DR or aggregated IgG supports the involvement of the class I major histocompatibility complex (MHC) expressed on the hepatocyte surface. | lld:pubmed |
| pubmed-article:3487021 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3487021 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3487021 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:3487021 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3487021 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3487021 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:3487021 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3487021 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3487021 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3487021 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3487021 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3487021 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3487021 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3487021 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:3487021 | pubmed:issn | 0106-9543 | lld:pubmed |
| pubmed-article:3487021 | pubmed:author | pubmed-author:MuscaAA | lld:pubmed |
| pubmed-article:3487021 | pubmed:author | pubmed-author:FrancoAA | lld:pubmed |
| pubmed-article:3487021 | pubmed:author | pubmed-author:BalsanoFF | lld:pubmed |
| pubmed-article:3487021 | pubmed:author | pubmed-author:BonavitaM SMS | lld:pubmed |
| pubmed-article:3487021 | pubmed:author | pubmed-author:BarnabaVV | lld:pubmed |
| pubmed-article:3487021 | pubmed:author | pubmed-author:LevreroMM | lld:pubmed |
| pubmed-article:3487021 | pubmed:author | pubmed-author:RubertiGG | lld:pubmed |
| pubmed-article:3487021 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3487021 | pubmed:volume | 6 | lld:pubmed |
| pubmed-article:3487021 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3487021 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3487021 | pubmed:pagination | 45-52 | lld:pubmed |
| pubmed-article:3487021 | pubmed:dateRevised | 2004-11-17 | lld:pubmed |
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| pubmed-article:3487021 | pubmed:meshHeading | pubmed-meshheading:3487021-... | lld:pubmed |
| pubmed-article:3487021 | pubmed:year | 1986 | lld:pubmed |
| pubmed-article:3487021 | pubmed:articleTitle | Characterization of effector cells in lymphocytotoxicity to autologous hepatocytes in HBsAg-positive and autoimmune chronic active hepatitis (CAH). | lld:pubmed |
| pubmed-article:3487021 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3487021 | lld:pubmed |
