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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1986-6-27
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pubmed:abstractText |
Peripheral blood lymphocyte subsets involved in cytotoxicity to autologous hepatocytes have been characterized by isolation on antibody-coated Petri dishes in autoimmune and HBsAg-positive chronic active hepatitis (CAH). In autoimmune CAH and in HBsAg-positive CAH without HBcAg in liver tissue, cytotoxicity is sustained by non-T lymphocytes and is confined to M1-positive cells bearing Fc receptors: M1 cytotoxicity inhibition by adding aggregated IgG suggests that these cells are responsible for an antibody-dependent cell-mediated mechanism (ADCC). Moreover, when T-enriched fractions were separated in T4, T8 and 5/9 positive subsets, only the first one showed a significant cytotoxicity: T4 positive cells might act as cytotoxic T cells or might be involved in delayed type hypersensitivity (DTH) reactions. Cytotoxic T lymphocytes in HBsAg-positive CAH with HBcAg in liver tissue are confined in T8 positive subset, while helper/inducer T cells (T4 positive or 5/9 positive) seem to play an important role only in the induction of cell-mediated injury against hepatocytes. The inhibition of T cell-cytotoxicity by preincubating liver cells with monoclonal antibody (Mab) anti-HLA AB and not with Mab anti-HLA DR or aggregated IgG supports the involvement of the class I major histocompatibility complex (MHC) expressed on the hepatocyte surface.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Monoclonal,
http://linkedlifedata.com/resource/pubmed/chemical/HLA Antigens,
http://linkedlifedata.com/resource/pubmed/chemical/HLA-A Antigens,
http://linkedlifedata.com/resource/pubmed/chemical/HLA-B Antigens,
http://linkedlifedata.com/resource/pubmed/chemical/HLA-DR Antigens,
http://linkedlifedata.com/resource/pubmed/chemical/Hepatitis B Surface Antigens,
http://linkedlifedata.com/resource/pubmed/chemical/Histocompatibility Antigens Class II,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin G,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Fc,
http://linkedlifedata.com/resource/pubmed/chemical/polymeric IgG
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0106-9543
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
6
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
45-52
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:3487021-Antibodies, Monoclonal,
pubmed-meshheading:3487021-Autoimmune Diseases,
pubmed-meshheading:3487021-Cytotoxicity, Immunologic,
pubmed-meshheading:3487021-Female,
pubmed-meshheading:3487021-HLA Antigens,
pubmed-meshheading:3487021-HLA-A Antigens,
pubmed-meshheading:3487021-HLA-B Antigens,
pubmed-meshheading:3487021-HLA-DR Antigens,
pubmed-meshheading:3487021-Hepatitis, Chronic,
pubmed-meshheading:3487021-Hepatitis B,
pubmed-meshheading:3487021-Hepatitis B Surface Antigens,
pubmed-meshheading:3487021-Histocompatibility Antigens Class II,
pubmed-meshheading:3487021-Humans,
pubmed-meshheading:3487021-Hypersensitivity, Delayed,
pubmed-meshheading:3487021-Immunoglobulin G,
pubmed-meshheading:3487021-Liver,
pubmed-meshheading:3487021-Receptors, Fc,
pubmed-meshheading:3487021-T-Lymphocytes,
pubmed-meshheading:3487021-T-Lymphocytes, Cytotoxic
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pubmed:year |
1986
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pubmed:articleTitle |
Characterization of effector cells in lymphocytotoxicity to autologous hepatocytes in HBsAg-positive and autoimmune chronic active hepatitis (CAH).
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pubmed:publicationType |
Journal Article
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