Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
1986-5-23
pubmed:databankReference
pubmed:abstractText
Factor VII is a precursor to a serine protease that is present in mammalian plasma. In its activated form, it participates in blood coagulation by activating factor X and/or factor IX in the presence of tissue factor and calcium. Clones coding for factor VII were obtained from two cDNA libraries prepared from poly(A) RNA from human liver and Hep G2 cells. The amino acid sequence deduced from the cDNAs indicates that factor VII is synthesized with a prepro-leader sequence of 60 or 38 amino acids. The mature protein that circulates in plasma is a single-chain polypeptide composed of 406 amino acids. The amino acid sequence analysis of the protein and the amino acid sequence deduced from the cDNAs indicate that factor VII is converted to factor VIIa by the cleavage of a single internal bond between arginine and isoleucine. This results in the formation of a light chain (152 amino acids) and a heavy chain (254 amino acids) that are held together by a disulfide bond. The light chain contains a gamma-carboxyglutamic acid (Gla) domain and two potential epidermal growth factor domains, while the heavy chain contains the serine protease portion of the molecule. Factor VII shows a high degree of amino acid sequence homology with the other vitamin K-dependent plasma proteins.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/3486420-1182130, http://linkedlifedata.com/resource/pubmed/commentcorrection/3486420-14023808, http://linkedlifedata.com/resource/pubmed/commentcorrection/3486420-234427, http://linkedlifedata.com/resource/pubmed/commentcorrection/3486420-271951, http://linkedlifedata.com/resource/pubmed/commentcorrection/3486420-271968, http://linkedlifedata.com/resource/pubmed/commentcorrection/3486420-291916, http://linkedlifedata.com/resource/pubmed/commentcorrection/3486420-2986678, http://linkedlifedata.com/resource/pubmed/commentcorrection/3486420-2989700, http://linkedlifedata.com/resource/pubmed/commentcorrection/3486420-2991859, http://linkedlifedata.com/resource/pubmed/commentcorrection/3486420-2991887, http://linkedlifedata.com/resource/pubmed/commentcorrection/3486420-2994716, http://linkedlifedata.com/resource/pubmed/commentcorrection/3486420-322279, http://linkedlifedata.com/resource/pubmed/commentcorrection/3486420-367103, http://linkedlifedata.com/resource/pubmed/commentcorrection/3486420-3894976, http://linkedlifedata.com/resource/pubmed/commentcorrection/3486420-4040611, http://linkedlifedata.com/resource/pubmed/commentcorrection/3486420-479368, http://linkedlifedata.com/resource/pubmed/commentcorrection/3486420-500719, http://linkedlifedata.com/resource/pubmed/commentcorrection/3486420-561632, http://linkedlifedata.com/resource/pubmed/commentcorrection/3486420-5760561, http://linkedlifedata.com/resource/pubmed/commentcorrection/3486420-6198242, http://linkedlifedata.com/resource/pubmed/commentcorrection/3486420-6203097, http://linkedlifedata.com/resource/pubmed/commentcorrection/3486420-6219389, http://linkedlifedata.com/resource/pubmed/commentcorrection/3486420-6246368, http://linkedlifedata.com/resource/pubmed/commentcorrection/3486420-6294139, http://linkedlifedata.com/resource/pubmed/commentcorrection/3486420-6305407, http://linkedlifedata.com/resource/pubmed/commentcorrection/3486420-6329734, http://linkedlifedata.com/resource/pubmed/commentcorrection/3486420-6356359, http://linkedlifedata.com/resource/pubmed/commentcorrection/3486420-6408124, http://linkedlifedata.com/resource/pubmed/commentcorrection/3486420-6438528, http://linkedlifedata.com/resource/pubmed/commentcorrection/3486420-6572939, http://linkedlifedata.com/resource/pubmed/commentcorrection/3486420-6587384, http://linkedlifedata.com/resource/pubmed/commentcorrection/3486420-6607417, http://linkedlifedata.com/resource/pubmed/commentcorrection/3486420-6688526, http://linkedlifedata.com/resource/pubmed/commentcorrection/3486420-6778860, http://linkedlifedata.com/resource/pubmed/commentcorrection/3486420-6795747, http://linkedlifedata.com/resource/pubmed/commentcorrection/3486420-6871167, http://linkedlifedata.com/resource/pubmed/commentcorrection/3486420-6959130, http://linkedlifedata.com/resource/pubmed/commentcorrection/3486420-7354023, http://linkedlifedata.com/resource/pubmed/commentcorrection/3486420-7372618, http://linkedlifedata.com/resource/pubmed/commentcorrection/3486420-836809, http://linkedlifedata.com/resource/pubmed/commentcorrection/3486420-901769, http://linkedlifedata.com/resource/pubmed/commentcorrection/3486420-956165
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0027-8424
pubmed:author
pubmed:issnType
Print
pubmed:volume
83
pubmed:owner
NLM
pubmed:authorsComplete
N
pubmed:pagination
2412-6
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1986
pubmed:articleTitle
Characterization of a cDNA coding for human factor VII.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't