Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1986-6-6
pubmed:abstractText
To study the role of class II MHC expression in mouse lymphomagenesis, we examined the cell surface expression of I-A/E antigens on 24 spontaneous or murine leukemia virus (MuLV)-induced mouse B10.A (I-Ak, I-Ek) B cell lymphomas. Two primary B10.A B cell lymphomas were observed with strong I-Ek expression but with only minimal cell surface I-Ak expression. Both tumors are readily transplantable in syngeneic mice, with maintenance of their I-A-, I-E+ phenotype. Strikingly, one I-A-, I-E+ B cell lymphoma contains a (11; 17) translocation with a breakpoint on chromosome 17 that is localized within or very close to the H-2 complex. DNA of both tumors contains normal restriction enzyme fragments of the A alpha and A beta genes. Northern blot analyses indicated that one I-A-, I-E+ tumor strongly expressed A alpha, E alpha, and E beta mRNAs but possessed only a weak expression of A beta mRNA. The other B cell lymphoma showed A beta, E alpha, and E beta mRNA expression but only minimal A alpha mRNA expression. In 11 primary B10.A B cell lymphomas with a normal I-A+, I-E+ phenotype, no imbalances in A alpha/A beta mRNA levels were observed. The implications of these findings for the role of class II MHC expression in mouse B cell lymphoma-genesis are discussed.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/3486245-197195, http://linkedlifedata.com/resource/pubmed/commentcorrection/3486245-219130, http://linkedlifedata.com/resource/pubmed/commentcorrection/3486245-2579225, http://linkedlifedata.com/resource/pubmed/commentcorrection/3486245-3873616, http://linkedlifedata.com/resource/pubmed/commentcorrection/3486245-3891902, http://linkedlifedata.com/resource/pubmed/commentcorrection/3486245-3921966, http://linkedlifedata.com/resource/pubmed/commentcorrection/3486245-398326, http://linkedlifedata.com/resource/pubmed/commentcorrection/3486245-398327, http://linkedlifedata.com/resource/pubmed/commentcorrection/3486245-479600, http://linkedlifedata.com/resource/pubmed/commentcorrection/3486245-567555, http://linkedlifedata.com/resource/pubmed/commentcorrection/3486245-6087163, http://linkedlifedata.com/resource/pubmed/commentcorrection/3486245-6171505, http://linkedlifedata.com/resource/pubmed/commentcorrection/3486245-6187128, http://linkedlifedata.com/resource/pubmed/commentcorrection/3486245-6202819, http://linkedlifedata.com/resource/pubmed/commentcorrection/3486245-6245301, http://linkedlifedata.com/resource/pubmed/commentcorrection/3486245-6245302, http://linkedlifedata.com/resource/pubmed/commentcorrection/3486245-6262410, http://linkedlifedata.com/resource/pubmed/commentcorrection/3486245-6268802, http://linkedlifedata.com/resource/pubmed/commentcorrection/3486245-6286762, http://linkedlifedata.com/resource/pubmed/commentcorrection/3486245-6289129, http://linkedlifedata.com/resource/pubmed/commentcorrection/3486245-6293111, http://linkedlifedata.com/resource/pubmed/commentcorrection/3486245-6297757, http://linkedlifedata.com/resource/pubmed/commentcorrection/3486245-6303968, http://linkedlifedata.com/resource/pubmed/commentcorrection/3486245-6311906, http://linkedlifedata.com/resource/pubmed/commentcorrection/3486245-6311935, http://linkedlifedata.com/resource/pubmed/commentcorrection/3486245-6323743, http://linkedlifedata.com/resource/pubmed/commentcorrection/3486245-6330738, http://linkedlifedata.com/resource/pubmed/commentcorrection/3486245-6333756, http://linkedlifedata.com/resource/pubmed/commentcorrection/3486245-6355856, http://linkedlifedata.com/resource/pubmed/commentcorrection/3486245-6402307, http://linkedlifedata.com/resource/pubmed/commentcorrection/3486245-6406638, http://linkedlifedata.com/resource/pubmed/commentcorrection/3486245-641338, http://linkedlifedata.com/resource/pubmed/commentcorrection/3486245-6421723, http://linkedlifedata.com/resource/pubmed/commentcorrection/3486245-6431411, http://linkedlifedata.com/resource/pubmed/commentcorrection/3486245-6605479, http://linkedlifedata.com/resource/pubmed/commentcorrection/3486245-6605691, http://linkedlifedata.com/resource/pubmed/commentcorrection/3486245-6606680, http://linkedlifedata.com/resource/pubmed/commentcorrection/3486245-6698640, http://linkedlifedata.com/resource/pubmed/commentcorrection/3486245-6752724, http://linkedlifedata.com/resource/pubmed/commentcorrection/3486245-6781910, http://linkedlifedata.com/resource/pubmed/commentcorrection/3486245-6787164, http://linkedlifedata.com/resource/pubmed/commentcorrection/3486245-6816725, http://linkedlifedata.com/resource/pubmed/commentcorrection/3486245-6935293, http://linkedlifedata.com/resource/pubmed/commentcorrection/3486245-7135466, http://linkedlifedata.com/resource/pubmed/commentcorrection/3486245-7188699, http://linkedlifedata.com/resource/pubmed/commentcorrection/3486245-7299345, http://linkedlifedata.com/resource/pubmed/commentcorrection/3486245-7333709, http://linkedlifedata.com/resource/pubmed/commentcorrection/3486245-7432518, http://linkedlifedata.com/resource/pubmed/commentcorrection/3486245-75239
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0022-1007
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
163
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1213-26
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
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