pubmed-article:3486012 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:3486012 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
pubmed-article:3486012 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
pubmed-article:3486012 | lifeskim:mentions | umls-concept:C0023467 | lld:lifeskim |
pubmed-article:3486012 | lifeskim:mentions | umls-concept:C0079460 | lld:lifeskim |
pubmed-article:3486012 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
pubmed-article:3486012 | lifeskim:mentions | umls-concept:C1514485 | lld:lifeskim |
pubmed-article:3486012 | pubmed:issue | 5 | lld:pubmed |
pubmed-article:3486012 | pubmed:dateCreated | 1986-6-6 | lld:pubmed |
pubmed-article:3486012 | pubmed:abstractText | Proliferation of acute myeloblastic leukemia (AML) cells in vitro is limited in most cases to a small subset of blasts that have several properties of stem cells. These leukemic colony-forming cells (AML-CFU) generally require addition of exogenous growth factors for proliferation in agar or methylcellulose. These factors can be supplied by media conditioned by phytohemagglutinin-stimulated normal leukocytes or by CSF-secreting tumor cell lines. However, the exact factor or factors required for stimulation of AML-CFU growth have not been defined. We compared the AML-CFU stimulatory activity of a human recombinant GM-CSF with that of GCT-CM, Mo-CM, and the PHA-leukocyte feeder system in 15 cases of AML. In each of the 12 cases that required exogenous growth factors for maximum AML-CFU growth, recombinant GM-CSF could replace either GM-CSF or Mo-CM, and could partially replace the PHA-leukocyte feeder system. These results indicate that this GM-CSF is a growth promoter of AML-CFU in these culture systems. | lld:pubmed |
pubmed-article:3486012 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:3486012 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:3486012 | pubmed:language | eng | lld:pubmed |
pubmed-article:3486012 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:3486012 | pubmed:citationSubset | AIM | lld:pubmed |
pubmed-article:3486012 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:3486012 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:3486012 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:3486012 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:3486012 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:3486012 | pubmed:month | May | lld:pubmed |
pubmed-article:3486012 | pubmed:issn | 0006-4971 | lld:pubmed |
pubmed-article:3486012 | pubmed:author | pubmed-author:WagnerKK | lld:pubmed |
pubmed-article:3486012 | pubmed:author | pubmed-author:YoungDD | lld:pubmed |
pubmed-article:3486012 | pubmed:author | pubmed-author:HerrmannFF | lld:pubmed |
pubmed-article:3486012 | pubmed:author | pubmed-author:GriffinJ DJD | lld:pubmed |
pubmed-article:3486012 | pubmed:author | pubmed-author:SabbathK DKD | lld:pubmed |
pubmed-article:3486012 | pubmed:author | pubmed-author:WiperDD | lld:pubmed |
pubmed-article:3486012 | pubmed:issnType | Print | lld:pubmed |
pubmed-article:3486012 | pubmed:volume | 67 | lld:pubmed |
pubmed-article:3486012 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:3486012 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:3486012 | pubmed:pagination | 1448-53 | lld:pubmed |
pubmed-article:3486012 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
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pubmed-article:3486012 | pubmed:year | 1986 | lld:pubmed |
pubmed-article:3486012 | pubmed:articleTitle | Effects of recombinant human GM-CSF on proliferation of clonogenic cells in acute myeloblastic leukemia. | lld:pubmed |
pubmed-article:3486012 | pubmed:publicationType | Journal Article | lld:pubmed |
pubmed-article:3486012 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
pubmed-article:3486012 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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