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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
1986-3-14
|
| pubmed:abstractText |
This study has examined the nature of the T lymphocytes and the alloantigens that induce the intestinal phase of graft-versus-host reaction in unirradiated F1 mice. Parental spleen cells were depleted of T cells subsets by treatment with anti-Lyt monoclonal antibodies and complement, and we show that Lyt 2- cells alone induce the increased lymphocytic infiltration of the epithelium that characterizes the intestinal graft-versus-host reaction. Lyt 2- cells are also required to induce some of the associated crypt hyperplasia, but the full crypt changes require both Lyt 2- and Lyt 2+ T cells. In intra-H-2 recombinant congenic F1 mice with graft-versus-host reaction, a disparity at the I-A locus was alone sufficient and necessary for crypt hyperplasia and increased intraepithelial lymphocyte counts, while an I-J incompatibility led to suppression of both these indices. The results support the hypothesis that the intestinal pathology of acute GVHD is induced by class II MHC-restricted delayed-type hypersensitivity effector T cells.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Feb
|
| pubmed:issn |
0041-1337
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
41
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
192-8
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:3484848-Animals,
pubmed-meshheading:3484848-Antigens, Ly,
pubmed-meshheading:3484848-Cell Cycle,
pubmed-meshheading:3484848-Epithelium,
pubmed-meshheading:3484848-Graft vs Host Disease,
pubmed-meshheading:3484848-Histocompatibility Antigens Class II,
pubmed-meshheading:3484848-Hypersensitivity,
pubmed-meshheading:3484848-Intestinal Mucosa,
pubmed-meshheading:3484848-Jejunum,
pubmed-meshheading:3484848-Leukocyte Count,
pubmed-meshheading:3484848-Lymphocyte Activation,
pubmed-meshheading:3484848-Mice,
pubmed-meshheading:3484848-Mice, Inbred A,
pubmed-meshheading:3484848-Mice, Inbred BALB C,
pubmed-meshheading:3484848-Mice, Inbred C57BL,
pubmed-meshheading:3484848-Mice, Inbred CBA,
pubmed-meshheading:3484848-Phenotype,
pubmed-meshheading:3484848-Splenomegaly,
pubmed-meshheading:3484848-T-Lymphocytes
|
| pubmed:year |
1986
|
| pubmed:articleTitle |
Hypersensitivity reactions in the small intestine. VII. Induction of the intestinal phase of murine graft-versus-host-reaction by Lyt 2- T cells activated by I-A alloantigens.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|