Linked Life Data

3484847

Source:http://linkedlifedata.com/resource/pubmed/id/3484847

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1986-3-20
pubmed:abstractText
Male Lewis rats were exposed from 1 to 6 weeks (3 hr/day, 5 days/week) to a Cd aerosol (1.6 mg Cd/m3). After the first week, there were significant elevations in airway amounts of lactic dehydrogenase, alkaline and acid phosphatase, protein, and polymorphonuclear leucocytes. After 2 weeks of exposures, airway cytological and biochemical alterations intensified and pulmonary histopathology was observed. The severity of pulmonary injury did not progress beyond this point, although Cd continued to accumulate in the lung in a linear fashion. During the next 3 weeks of exposures, airway alterations diminished and lung histology became normal, suggesting that pulmonary adaptation to Cd might have occurred. Cd-binding proteins, with properties similar to hepatic metallothionein (MT), were isolated from the lungs of Cd-exposed animals. Pulmonary MT quantities increased significantly with repeated exposure to Cd. Sequestration of Cd by MT may be involved in the partial resolution of the lung injury. Translocation of Cd to the liver and kidney also occurred following inhalation exposure. Prior Cd inhalation exposure increased Cd translocation to the kidney, but not to the liver. Liver and kidney Cd burdens increased during the 6 weeks of Cd exposure. MT values also rose but hepatic MT quantities increased faster and to a greater extent than renal MT quantities.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0041-008X
pubmed:author
pubmed:issnType
Print
pubmed:volume
82
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
281-91
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1986
pubmed:articleTitle
Cellular and biochemical response of the rat lung to repeated inhalation of cadmium.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.