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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
1986-3-21
|
| pubmed:abstractText |
In this paper, we describe a study of the therapeutic parameters (dose and schedule) and immunomodulatory activity (macrophage, natural killer cell, and T-cell number and function) of polyinosinic-polycytidylic acid admixed with poly-L-lysine and solubilized with carboxymethyl cellulose [poly(I,C)-LC] in the treatment of MBL-2 tumor ascites. Tumor-bearing mice received an optimal therapeutic protocol [100 micrograms poly(I,C)-LC administered twice a wk], a maximum tolerated dose [50 micrograms poly(I,C)-LC administered daily], or the optimal immunomodulatory protocol for normal mice [10 micrograms poly(I,C)-LC administered daily]. The percentage of tumor-associated macrophages and their cytotoxic activity correlated with host survival. In addition, splenic T-cell activity correlated with host survival, and splenic natural killer cell function had a near significant correlation with host survival. These results indicate that the optimal dose and schedule of poly(I,C)-LC for immunomodulation in tumor-bearing animals are also the optimal therapeutic protocol but have less toxicity than the maximum tolerated dose.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Mar
|
| pubmed:issn |
0008-5472
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
46
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1331-8
|
| pubmed:dateRevised |
2010-11-18
|
| pubmed:meshHeading |
pubmed-meshheading:3484679-Animals,
pubmed-meshheading:3484679-Ascites,
pubmed-meshheading:3484679-Carboxymethylcellulose Sodium,
pubmed-meshheading:3484679-Cytotoxicity, Immunologic,
pubmed-meshheading:3484679-Dose-Response Relationship, Drug,
pubmed-meshheading:3484679-Granulocytes,
pubmed-meshheading:3484679-Immunity, Cellular,
pubmed-meshheading:3484679-Immunotherapy,
pubmed-meshheading:3484679-Leukocyte Count,
pubmed-meshheading:3484679-Lymphocytes,
pubmed-meshheading:3484679-Macrophages,
pubmed-meshheading:3484679-Male,
pubmed-meshheading:3484679-Mice,
pubmed-meshheading:3484679-Neoplasms, Experimental,
pubmed-meshheading:3484679-Peritoneal Cavity,
pubmed-meshheading:3484679-Poly I-C,
pubmed-meshheading:3484679-Polylysine,
pubmed-meshheading:3484679-Solubility,
pubmed-meshheading:3484679-T-Lymphocytes, Cytotoxic
|
| pubmed:year |
1986
|
| pubmed:articleTitle |
Dissociation of therapeutic and toxic effects of polyinosinic-polycytidylic acid admixed with poly-L-lysine and solubilized with carboxymethyl cellulose in tumor-bearing mice.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
|