Linked Life Data

3484666

Source:http://linkedlifedata.com/resource/pubmed/id/3484666

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3-4
pubmed:dateCreated
1986-3-7
pubmed:abstractText
Trisomy 15 is a frequent chromosomal abnormality found in murine thymic tumors that develop spontaneously or by induction with irradiation, chemical carcinogens, or leukemogenic retroviruses. The results of our studies demonstrate that T-cell lymphomas induced in RF mice with the chemical carcinogen 3-methylcholanthrene predominantly exhibit a normal diploid complement of chromosomes with no evidence of chromosome 15 trisomy after in vivo and in vitro passage. We conclude that accumulation of aneuploidy is not necessary for maintenance of the tumor phenotype and that chemically induced lymphomas can develop in a defined subpopulation of T cells in the absence of trisomy 15.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0165-4608
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
19
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
205-11
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1986
pubmed:articleTitle
Absence of trisomy 15 in chemically induced murine T-cell lymphomas.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.