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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
5
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pubmed:dateCreated |
1987-12-18
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pubmed:abstractText |
An empiric power function relationship between a population's mean density (m) and its corresponding variance (v), written v = a.mb (a, b, constants), may be applied to the analysis of experimentally induced pulmonary metastases within syngeneic (C57BL/6 X C3H)F1 mice. The mean and variance of the numbers of resultant B16 F1 and B16 F10 melanoma metastases strongly correlated with the power function (r2 greater than 0.8). The exponent b was 1.4 +/- 0.1 and 1.6 +/- 0.2 for the F1 and F10 melanomas, respectively, indicating a clustering of metastases within certain mice. This clustering of metastases within more highly affected animals may reflect a diffusion-limited aggregation of tumor cells within the circulation and the resultant greater ability of these aggregates to form metastases.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0027-8874
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
79
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1113-5
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:3479636-Animals,
pubmed-meshheading:3479636-Cell Aggregation,
pubmed-meshheading:3479636-Female,
pubmed-meshheading:3479636-Melanoma, Experimental,
pubmed-meshheading:3479636-Mice,
pubmed-meshheading:3479636-Mice, Inbred C3H,
pubmed-meshheading:3479636-Mice, Inbred C57BL,
pubmed-meshheading:3479636-Neoplasm Metastasis,
pubmed-meshheading:3479636-Neoplasm Transplantation,
pubmed-meshheading:3479636-Probability,
pubmed-meshheading:3479636-Tumor Cells, Cultured
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pubmed:year |
1987
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pubmed:articleTitle |
Experimental metastasis: a novel application of the variance-to-mean power function.
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pubmed:affiliation |
Department of Cell Biology, University of Texas M.D. Anderson Hospital and Tumor Institute, Houston 77030.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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