Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1987-12-18
pubmed:abstractText
An empiric power function relationship between a population's mean density (m) and its corresponding variance (v), written v = a.mb (a, b, constants), may be applied to the analysis of experimentally induced pulmonary metastases within syngeneic (C57BL/6 X C3H)F1 mice. The mean and variance of the numbers of resultant B16 F1 and B16 F10 melanoma metastases strongly correlated with the power function (r2 greater than 0.8). The exponent b was 1.4 +/- 0.1 and 1.6 +/- 0.2 for the F1 and F10 melanomas, respectively, indicating a clustering of metastases within certain mice. This clustering of metastases within more highly affected animals may reflect a diffusion-limited aggregation of tumor cells within the circulation and the resultant greater ability of these aggregates to form metastases.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0027-8874
pubmed:author
pubmed:issnType
Print
pubmed:volume
79
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1113-5
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1987
pubmed:articleTitle
Experimental metastasis: a novel application of the variance-to-mean power function.
pubmed:affiliation
Department of Cell Biology, University of Texas M.D. Anderson Hospital and Tumor Institute, Houston 77030.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't