|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0006556,
umls-concept:C0007595,
umls-concept:C0009017,
umls-concept:C0025248,
umls-concept:C0122610,
umls-concept:C0205307,
umls-concept:C0332307,
umls-concept:C0597032,
umls-concept:C0679058,
umls-concept:C1314939,
umls-concept:C1420192,
umls-concept:C1547699,
umls-concept:C2700640
|
|
pubmed:issue |
18
|
|
pubmed:dateCreated |
1987-10-15
|
|
pubmed:databankReference |
|
|
pubmed:abstractText |
Complementary DNA (cDNA) clones encoding the heavy chain of the heterodimeric human membrane glycoprotein 4F2 have been isolated by immunoscreening of a lambda gt11 expression library. The identity of these clones has been confirmed by hybridization to RNA and DNA prepared from mouse L-cell transfectants, which were produced by whole cell gene transfer and selected for cell-surface expression of the human 4F2 heavy chain. DNA sequence analysis suggests that the 4F2 heavy-chain cDNAs encode an approximately 526-amino acid type II membrane glycoprotein, which is composed of a large C-terminal extracellular domain, a single potential transmembrane region, and a 50-81 amino acid N-terminal intracytoplasmic domain. Southern blotting experiments have shown that the 4F2 heavy-chain cDNAs are derived from a single-copy gene that has been highly conserved during mammalian evolution.
|
|
pubmed:grant |
|
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/3476959,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3476959-1062804,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3476959-206705,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3476959-2415610,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3476959-2416754,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3476959-2417704,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3476959-2423603,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3476959-2423876,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3476959-271968,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3476959-2983222,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3476959-3001694,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3476959-3093892,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3476959-3487571,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3476959-3492555,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3476959-3551881,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3476959-3871253,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3476959-3950410,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3476959-3980986,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3476959-4029274,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3476959-6090955,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3476959-6095287,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3476959-6167991,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3476959-6177771,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3476959-6188154,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3476959-6219389,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3476959-6253938,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3476959-6258155,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3476959-6272317,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3476959-6296263,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3476959-6310343,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3476959-6586420,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3476959-6680152,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3476959-6694911,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3476959-6855576,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3476959-7204970
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Sep
|
|
pubmed:issn |
0027-8424
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
84
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
6526-30
|
|
pubmed:dateRevised |
2010-11-18
|
|
pubmed:meshHeading |
pubmed-meshheading:3476959-Amino Acid Sequence,
pubmed-meshheading:3476959-Animals,
pubmed-meshheading:3476959-Antigens, Surface,
pubmed-meshheading:3476959-Base Sequence,
pubmed-meshheading:3476959-Biological Evolution,
pubmed-meshheading:3476959-Cell Division,
pubmed-meshheading:3476959-Cloning, Molecular,
pubmed-meshheading:3476959-DNA,
pubmed-meshheading:3476959-Glycoproteins,
pubmed-meshheading:3476959-Humans,
pubmed-meshheading:3476959-Membrane Proteins,
pubmed-meshheading:3476959-Mice
|
|
pubmed:year |
1987
|
|
pubmed:articleTitle |
Molecular cloning of complementary DNAs encoding the heavy chain of the human 4F2 cell-surface antigen: a type II membrane glycoprotein involved in normal and neoplastic cell growth.
|
|
pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|
