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rdf:type |
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lifeskim:mentions |
umls-concept:C0007589,
umls-concept:C0007634,
umls-concept:C0023440,
umls-concept:C0025914,
umls-concept:C0026809,
umls-concept:C0079382,
umls-concept:C0521449,
umls-concept:C1314939,
umls-concept:C1511938,
umls-concept:C1516960,
umls-concept:C1521761
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pubmed:issue |
18
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pubmed:dateCreated |
1987-10-15
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pubmed:abstractText |
A previous report described an intracellular factor (differentiation-inducing factor I, or DIF-I) that seems to play a role in erythroid differentiation in mouse erythroleukemia (MEL) cells. We have detected another erythroid-inducing factor in cell-free extracts from dimethyl sulfoxide- or hexamethylenebis(acetamide)-treated MEL cells, which acts synergistically with DIF-I. The partially purified factor (termed DIF-II) triggered erythroid differentiation when introduced into undifferentiated MEL cells that had been potentiated by the induction of DIF-I. The activity in the extracts appeared in an inducible manner after addition of dimethyl sulfoxide or hexamethylenebis(acetamide), reached a maximum at 6 hr, and then rapidly decreased. The induction was inhibited by phorbol 12-myristate 13-acetate and also by cycloheximide. No induction was observed in a mutant MEL cell line defective in erythroid differentiation. These characteristics are consistent with the supposition that DIF-II is one of the putative dimethyl sulfoxide-inducible factors detected in previously reported cell-fusion and cytoplast-fusion experiments. The role of DIF-II in MEL-cell differentiation and in vitro differentiation in general is discussed.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/3476957-1056809,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3476957-1062798,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3476957-1240809,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3476957-164031,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3476957-177980,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3476957-2420621,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3476957-271073,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3476957-272229,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3476957-276884,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3476957-307692,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3476957-3456277,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3476957-3457564,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3476957-3458027,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3476957-3458243,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3476957-3458709,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3476957-3462732,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3476957-3528861,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3476957-3528863,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3476957-3529085,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3476957-3860863,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3476957-3861323,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3476957-5277089,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3476957-5920633,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3476957-6154532,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3476957-6462247,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3476957-6571994,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3476957-6594696,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3476957-6626512,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3476957-6713378,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3476957-683306,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3476957-6930535,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3476957-7110336,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3476957-75063
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
84
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
6481-5
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:3476957-Animals,
pubmed-meshheading:3476957-Cell Differentiation,
pubmed-meshheading:3476957-Cytoplasm,
pubmed-meshheading:3476957-Dimethyl Sulfoxide,
pubmed-meshheading:3476957-Erythropoiesis,
pubmed-meshheading:3476957-Leukemia, Erythroblastic, Acute,
pubmed-meshheading:3476957-Mice,
pubmed-meshheading:3476957-Molecular Weight,
pubmed-meshheading:3476957-Proteins,
pubmed-meshheading:3476957-Time Factors
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pubmed:year |
1987
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pubmed:articleTitle |
Dimethyl sulfoxide-inducible cytoplasmic factor involved in erythroid differentiation in mouse erythroleukemia (Friend) cells.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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