Switch to
Predicate | Object |
---|---|
rdf:type | |
lifeskim:mentions | |
pubmed:issue |
9
|
pubmed:dateCreated |
1987-10-21
|
pubmed:abstractText |
One hundred thirty-three children with acute myelogenous leukemia (AML) entered the multicenter Pediatric Branch of the Italian Association Against Leukemia trial AIEOP/LAM 8204 between July 1982 and May 1986. Induction therapy consisted of two courses of daunomycin (DNM) plus cytosine arabinoside (Ara-C). Those patients who achieved remission were given four courses of consolidation with DNM, 6-thioguanine (6-TG) and escalated doses of Ara-C followed by six courses of sequential continuation therapy using monthly pairs: etoposide (VP-16)/Ara-C, Ara-C/6-TG, and DNM/Ara-C. Periodic intrathecal Ara-C was used for CNS prophylaxis. One hundred seven (80%) children achieved complete remission (CR). Kaplan-Meier estimates of 3-year disease-free survival (DFS) and event-free survival (EFS) are 41% and 33%, respectively. Relapses occurred in 34 patients after 5 to 97 weeks (32 marrow; 2 marrow plus CNS). Overall, 14 patients died of complications during treatment (nine during induction; five during the postremission phase), mostly from infection. Risk factor analysis showed that induction failures occurred predominantly in children with French-American-British (FAB) M5 and in those with elevated leukocyte counts; by step-up Cox analysis, only FAB subtype was predictive of remission success. None of the variables examined was significant for predicting the duration of remission. Hyperleukocytosis was predictive of a significantly worse EFS rate. These results are encouraging and further support the use of intensive chemotherapy programs for childhood AML.
|
pubmed:language |
eng
|
pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
Sep
|
pubmed:issn |
0732-183X
|
pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
5
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
1356-63
|
pubmed:dateRevised |
2007-11-15
|
pubmed:meshHeading |
pubmed-meshheading:3476689-Adolescent,
pubmed-meshheading:3476689-Antineoplastic Combined Chemotherapy Protocols,
pubmed-meshheading:3476689-Child,
pubmed-meshheading:3476689-Child, Preschool,
pubmed-meshheading:3476689-Cytarabine,
pubmed-meshheading:3476689-Daunorubicin,
pubmed-meshheading:3476689-Drug Administration Schedule,
pubmed-meshheading:3476689-Etoposide,
pubmed-meshheading:3476689-Female,
pubmed-meshheading:3476689-Humans,
pubmed-meshheading:3476689-Infant,
pubmed-meshheading:3476689-Leukemia, Myeloid, Acute,
pubmed-meshheading:3476689-Male,
pubmed-meshheading:3476689-Remission Induction,
pubmed-meshheading:3476689-Thioguanine
|
pubmed:year |
1987
|
pubmed:articleTitle |
Treatment of acute myelogenous leukemia in children: results of the Italian Cooperative Study AIEOP/LAM 8204.
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|