Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
16
pubmed:dateCreated
1987-9-18
pubmed:abstractText
Transcription of the rat growth hormone (rGH) gene in pituitary cells is increased by addition of thyroid hormone (T3). This induction is dependent on the presence of specific sequences just upstream of the rGH promoter. We have partially purified T3 receptor from rat liver and examined its interaction with these rGH sequences. We show here that T3 receptor binds specifically to a site just upstream of the basal rGH promoter. This binding site includes two copies of a 7-base-pair direct repeat, the centers of which are separated by 10 base pairs. Deletions that specifically remove the T3 receptor binding site drastically reduce response to T3 in transient transfection experiments. These results demonstrate that T3 receptor can recognize specific DNA sequences and suggest that it can act directly as a positive transcriptional regulatory factor.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/3475698-197105, http://linkedlifedata.com/resource/pubmed/commentcorrection/3475698-2420797, http://linkedlifedata.com/resource/pubmed/commentcorrection/3475698-2428817, http://linkedlifedata.com/resource/pubmed/commentcorrection/3475698-2879242, http://linkedlifedata.com/resource/pubmed/commentcorrection/3475698-2879243, http://linkedlifedata.com/resource/pubmed/commentcorrection/3475698-2879246, http://linkedlifedata.com/resource/pubmed/commentcorrection/3475698-2992803, http://linkedlifedata.com/resource/pubmed/commentcorrection/3475698-2995348, http://linkedlifedata.com/resource/pubmed/commentcorrection/3475698-3009429, http://linkedlifedata.com/resource/pubmed/commentcorrection/3475698-3023965, http://linkedlifedata.com/resource/pubmed/commentcorrection/3475698-3464596, http://linkedlifedata.com/resource/pubmed/commentcorrection/3475698-3466175, http://linkedlifedata.com/resource/pubmed/commentcorrection/3475698-3733710, http://linkedlifedata.com/resource/pubmed/commentcorrection/3475698-3837180, http://linkedlifedata.com/resource/pubmed/commentcorrection/3475698-3981636, http://linkedlifedata.com/resource/pubmed/commentcorrection/3475698-4372251, http://linkedlifedata.com/resource/pubmed/commentcorrection/3475698-6088072, http://linkedlifedata.com/resource/pubmed/commentcorrection/3475698-6092333, http://linkedlifedata.com/resource/pubmed/commentcorrection/3475698-6190571, http://linkedlifedata.com/resource/pubmed/commentcorrection/3475698-6192932, http://linkedlifedata.com/resource/pubmed/commentcorrection/3475698-6236744, http://linkedlifedata.com/resource/pubmed/commentcorrection/3475698-6248238, http://linkedlifedata.com/resource/pubmed/commentcorrection/3475698-6269071, http://linkedlifedata.com/resource/pubmed/commentcorrection/3475698-6275366, http://linkedlifedata.com/resource/pubmed/commentcorrection/3475698-6310405, http://linkedlifedata.com/resource/pubmed/commentcorrection/3475698-6317184, http://linkedlifedata.com/resource/pubmed/commentcorrection/3475698-6327674, http://linkedlifedata.com/resource/pubmed/commentcorrection/3475698-6540146, http://linkedlifedata.com/resource/pubmed/commentcorrection/3475698-942051
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0027-8424
pubmed:author
pubmed:issnType
Print
pubmed:volume
84
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
5670-4
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1987
pubmed:articleTitle
Thyroid hormone receptor binds to a site in the rat growth hormone promoter required for induction by thyroid hormone.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't